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EPS15 Antibody

EPS15 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameEPS15 Primary Polyclonal Antibody
Also known asEPS15 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenEPS15
SpecificityThis is a highly specific antibody against EPS15
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EPS15
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Eps15 is capable of binding the amino terminal portion of Crk via a conserved proline-rich domain, Eps8 and Eps15 are proteins, Eps8 has been shown to associate with the EGF receptor despite its lack of a functional SH2 domain, Further characterization suggests the protein has both a PH domain and a SH3 domain, Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer, Overexpression of Eps15 in NIH/3T3 cells causes cellular transformation, Overexpression of Eps8 in both fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF, Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, characteristic of all Crk binding proteins (5), have been described, implying involvement in the regulation of cell proliferation, or Eps8 and Eps15, respectively that become tyrosine phosphorylated subsequent to EGF stimulation, the functional significance of which are not yet known, Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AF 1p protein, AF1P, ALL1 fused gene from chromosome 1, EPS 15, EPS15_HUMAN, Epidermal growth factor receptor pathway substrate 15, Epidermal growth factor receptor substrate 15, MLLT 5, MLLT5, Protein Eps 15, Protein Eps15, AF 1P
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetEPS15
Short nameEPS15 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameEPS15 (Antibody to)
Alternative techniqueantibodies
Identity 3419
Gene EPS15
Long gene name epidermal growth factor receptor pathway substrate 15
Synonyms AF-1P MLLT5
Locus 1p32, 3
Discovery year 1994-12-19
GenBank acession BC054006
Entrez gene record 2060
Pubmed identfication 8183552
RefSeq identity NM_001981
Classification EF-hand domain containing
Havana BLAST/BLAT OTTHUMG00000008192

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