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EPS8 Antibody

EPS8 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameEPS8 Primary Polyclonal Antibody
Also known asEPS8 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenEPS8
SpecificityThis is a highly specific antibody against EPS8
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range270-320/822
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EPS8
Gene ID number2059
Swiss ProtQ12929
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context, Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, Also shows actin bundling activity when associated with BAIAP2, Component of a complex with DFNB31 and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core, Depending on its association with other signal transducers, Displays barbed-end actin capping activity when associated with ABI1, In contrast, Indirectly involved in cell cycle progression, Involved in the regulation of processes such as axonal filopodia growth, Together with SOS1 and ABI1, can regulate different processes, dendritic cell migration and cancer cell migration and invasion, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation, its degradation following ubiquitination being required during G2 phase to promote cell shape changes, negatively regulates axonal filopodia formation via actin-capping activity, stereocilia length, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction, Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names EPS8, Epidermal growth factor receptor kinase substrate 8, DFNB102
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetEPS8
Short nameEPS8 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameEPS8 (Antibody to)
Alternative techniqueantibodies
Identity 3420
Gene EPS8
Long gene name epidermal growth factor receptor pathway substrate 8
Locus 12p12, 3
Discovery year 1994-12-19
GenBank acession U12535
Entrez gene record 2059
Pubmed identfication 8084614
Havana BLAST/BLAT OTTHUMG00000168787

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