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EPS8 Antibody, FITC Conjugated

EPS8 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, EPS8 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenEPS8
SpecificityThis is a highly specific antibody against EPS8
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range270-320/822
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human EPS8
Gene ID number2059
Swiss ProtQ12929
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context, Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, Also shows actin bundling activity when associated with BAIAP2, Component of a complex with DFNB31 and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core, Depending on its association with other signal transducers, Displays barbed-end actin capping activity when associated with ABI1, In contrast, Indirectly involved in cell cycle progression, Involved in the regulation of processes such as axonal filopodia growth, Together with SOS1 and ABI1, can regulate different processes, dendritic cell migration and cancer cell migration and invasion, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation, its degradation following ubiquitination being required during G2 phase to promote cell shape changes, negatively regulates axonal filopodia formation via actin-capping activity, stereocilia length, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction, Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetEPS8 Conjugated
Short name FITC Conjugated, EPS8 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, EPS8 (Antibody to)
Alternative techniqueantibodies
Identity 3420
Gene EPS8
Long gene name epidermal growth factor receptor pathway substrate 8
Locus 12p12, 3
Discovery year 1994-12-19
GenBank acession U12535
Entrez gene record 2059
Pubmed identfication 8084614
Havana BLAST/BLAT OTTHUMG00000168787

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