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ErbB-3/HER3 Antibody, Biotin Conjugated

ErbB-3/HER3 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, ErbB-3/HER3 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenErbB-3/HER3
SpecificityThis is a highly specific antibody against ErbB-3/HER3
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range670-720/1342
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human ErbB-3
Gene ID number2065
Swiss ProtP21860
Tested applicationsIHC-P
Recommended dilutionsIHC-P(1:100-500)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Additional splice variants have also been reported but they have not been thoroughly characterized, Alternate transcriptional splice variants encoding different isoforms have been characterized, Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain, Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation, However it does form heterodimers with other EGF receptor family members which do have kinase activity, It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation, One isoform lacks the intermembrane region and is secreted outside the cell, This form acts to modulate the activity of the membrane-bound form, bladder and breast tumors, The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms HER3
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetErbB-3/HER3 Conjugated
Short name Conjugated, ErbB-3/HER3 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, ErbB-3/HER3 (Antibody to)
Alternative techniqueantibodies
Identity 3431
Gene ERBB3
Long gene name erb-b2 receptor tyrosine kinase 3
Synonyms gene LCCS2
Synonyms gene name lethal congenital contracture syndrome 2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Synonyms name human epidermal growth factor receptor 3
Locus 12q13, 2
Discovery year 1990-07-15
GenBank acession M34309
Entrez gene record 2065
RefSeq identity NM_001982
Classification Erb-b2 receptor tyrosine kinases
Havana BLAST/BLAT OTTHUMG00000170140
Locus Specific Databases LRG_996

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