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ErbB2 Antibody

ErbB2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameErbB2 Primary Polyclonal Antibody
Also known asErbB2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenErbB2
SpecificityThis is a highly specific antibody against ErbB2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range160-200/1255
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ErbB2
Gene ID number2064
Swiss ProtP04626
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription, Essential component of a neuregulin-receptor complex, GP30 is a potential ligand for this receptor, Implicated in transcriptional activation of CDKN1A, In the nucleus is involved in transcriptional regulation, In turn, Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth, Regulates outgrowth and stabilization of peripheral microtubules (MTs), This prevents the phosphorylation of APC and CLASP2, Upon ERBB2 activation, allowing its association with the cell membrane, although neuregulins do not interact with it alone, but that apparently needs a coreceptor for ligand binding, membrane-bound APC allows the localization of MACF1 to the cell membrane, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, the function involves STAT3 and SRC, which is required for microtubule capture and stabilization, Protein tyrosine kinase that is part of several cell surface receptor complexes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CD340, ERBB2, HER-2, HER-2/neu, HER2, MLN 19, MLN19, Metastatic lymph node gene 19 protein, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, NEU
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetErbB2
Short nameErbB2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name neuro/glioblastoma derived oncogene homolog (avian) (Antibody to), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
Alternative techniqueantibodies
Identity 15842
Gene ERBIN
Long gene name erbb2 interacting protein
Synonyms gene ERBB2IP
Synonyms gene name erbb2-interacting protein
Synonyms LAP2
Synonyms name densin-180-like protein ERBB2-interacting protein
Locus 5q12, 3
Discovery year 2001-06-18
Entrez gene record 55914
Pubmed identfication 10574462 10878805
RefSeq identity NM_018695
Classification PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000097808

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