| Long name | ERCC6 Primary Polyclonal Antibody |
| Also known as | ERCC6 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ERCC6 |
| Specificity | This is a highly specific antibody against ERCC6 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 240-275/1493 |
| Subcellular location | Nucleus |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ERCC6 |
| Gene ID number | 2074 |
| Swiss Prot | Q03468 |
| Tested Applications | IF(IHC-P), IHC-P |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | It is required for transcription-coupled repair complex formation, It recruits the CSA complex (DCX(ERCC8) complex), Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions, thereby modifying the interface between stalled RNA polymerase II and DNA, Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ARMD5, ATP-dependent helicase ERCC6, CKN2, COFS, COFS1, Cockayne syndrome protein CSB, DNA excision repair protein ERCC-6, ERCC6, RAD26, UVSS1, CSB |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | ERCC6 |
| Short name | ERCC6 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | complementation family 6 (Antibody to), excision repair cross-complementing rodent repair deficiency |
| Alternative technique | antibodies |
| Alternative to gene target | ARMD5 and CKN2 and COFS and COFS1 and CSB and RAD26 and UVSS1, ERCC6 and IDBG-304121 and ENSG00000225830 and 2074, ERCC6 and IDBG-631777 and ENSBTAG00000032527 and 522908, Ercc6 and IDBG-147857 and ENSMUSG00000054051 and 319955, complementation group 6, elongation and biological process this GO :0032786 and positive regulation of DNA-templated transcription, elongation and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0045494 and photoreceptor cell maintenance and biological process this GO :0047485 and protein N-terminus binding and molecular function, nuclei, protein N-terminus binding, this GO :0000303 and response to superoxide and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0004386 and helicase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006283 and transcription-coupled nucleotide-excision repair and biological process this GO :0006284 and base-excision repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006290 and pyrimidine dimer repair and biological process this GO :0006362 and transcription elongation from RNA polymerase I promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007256 and activation of JNKK activity and biological process this GO :0007257 and activation of JUN kinase activity and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008023 and transcription elongation factor complex and cellular component this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009411 and response to UV and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010165 and response to X-ray and biological process this GO :0010224 and response to UV-B and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032784 and regulation of DNA-templated transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0004386: helicase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008022: protein C-terminus binding and also this GO :0008094: DNA-dependent ATPase activity and also this GO :0032403: protein complex binding and also this GO :0047485: protein N-terminus binding, this GO :0003682: chromatin binding, this GO :0004386: helicase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008022: protein C-terminus binding, this GO :0008094: DNA-dependent ATPase activity, this GO :0032403: protein complex binding, this GO :0047485: protein N-terminus binding, excision repair cross-complementing rodent repair deficiency |
| Identity | 3438 |
| Gene | ERCC6 |
| Long gene name | ERCC excision repair 6, chromatin remodeling factor |
| Synonyms gene | CKN2 |
| Synonyms gene name | complementation group 6 excision repair cross-complementation group 6 , excision repair cross-complementing rodent repair deficiency |
| Synonyms | CSB RAD26 ARMD5 |
| Synonyms name | Cockayne syndrome B protein |
| Locus | 10q11, 23 |
| Discovery year | 1989-06-30 |
| GenBank acession | L04791 |
| Entrez gene record | 2074 |
| Pubmed identfication | 1339317 19179336 |
| RefSeq identity | NM_000124 |
| Classification | ERCC excision repair associated |
| Havana BLAST/BLAT | OTTHUMG00000018195 |
| Locus Specific Databases | LRG_465 |
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