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ERK1 + ERK2 Antibody

ERK1 + ERK2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameERK1 + ERK2 Primary Polyclonal Antibody
Also known asERK1 + ERK2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenERK1 + ERK2
SpecificityThis is a highly specific antibody against ERK1 + ERK2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range330-358/358
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from mouse ERK2
Gene ID number26413
Swiss ProtP63085
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen About 160 substrates have already been discovered for ERKs, Depending on the cellular context, However, MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade, Many of these substrates are localized in the nucleus, Moreover, The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF, adhesion, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors, and seem to participate in the regulation of transcription upon stimulation, and those are responsible for processes such as translation, as well as in the fragmentation of the Golgi apparatus during mitosis, cytoskeletal rearrangements, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), mitosis, mitosis and apoptosis, other substrates are found in the cytosol as well as in other cellular organelles, survival and differentiation through the regulation of transcription, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, translation, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ERK-2, ERT1, Erk2, Extracellular signal-regulated kinase 2, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MAPK 2, Mapk, Mapk1, Mitogen-activated protein kinase 2, Prkm1, p42-MAPK, Mitogen-activated protein kinase 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetERK1 + ERK2
Short nameERK1 + ERK2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameERK1 and ERK2 (Antibody to)
Alternative techniqueantibodies
Identity 6871
Gene MAPK1
Long gene name mitogen-activated protein kinase 1
Synonyms gene PRKM2 PRKM1
Synonyms ERK ERK2 p41mapk MAPK2
Locus 22q11, 22
Discovery year 1993-11-05
GenBank acession M84489
Entrez gene record 5594
Classification Mitogen-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000030508
Locus Specific Databases LRG_786

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