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ERK5 (Ser731+Thr733) Antibody

ERK5 (Ser731+Thr733) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameERK5 (Ser731+Thr733) Primary Polyclonal Antibody
Also known asERK5 (Ser731+Thr733) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenERK5 Ser731+Thr733
Specificity Recognizes Ser721+Thr723 in mice and rats, This is a highly specific antibody against ERK5 Ser731+Thr733
Modification(s)Phosphorylation
Modification site(s)Ser731+Thr733
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range725-740/816
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation sites of Ser731+Thr733
Gene ID number5598
Swiss ProtQ13164
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway, Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction, MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways, May be important for endothelial function and maintenance of blood vessel integrity, May have a role in muscle cell differentiation, Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression, The upstream activator of MAPK7 is the MAPK kinase MAP2K5, Upon activation, differentiation and cell survival, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C, Plays a role in various cellular processes such as proliferation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BMK-1, Big MAP kinase 1, ERK-5, ERK4, ERK5, Extracellular signal-regulated kinase 5, MAP kinase 7, MAPK 7, MAPK7, Mitogen-activated protein kinase 7, PRKM7, BMK1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetERK5 (Ser731+Thr733)
Short nameERK5 (Ser731+Thr733) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameERK5 (Ser731+Thr733) (Antibody to)
Alternative techniqueantibodies
Identity 6880
Gene MAPK7
Long gene name mitogen-activated protein kinase 7
Synonyms gene PRKM7
Synonyms BMK1 ERK5
Synonyms name BMK1 kinase extracellular-signal-regulated kinase 5
Locus 17p11, 2
Discovery year 1998-04-28
GenBank acession U25278
Entrez gene record 5598
Pubmed identfication 10072598 7759517
RefSeq identity NM_139033
Classification Mitogen-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000059587

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