ESR1/ER (415CT16.3.2.1) Monoclonal Antibody

ESR1/ER (415CT16.3.2.1) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 211

Size 0.1ml

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Long name	1) Monoclonal Antibody, 2, 3, ESR1/ER (415CT16
Also known as	1) Monoclonal Antibody, 2, 3, ESR1/ER (415CT16
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	ESR1/ER
Specificity	This is a highly specific antibody against ESR1/ER
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Monoclonal
Clone number	1, 2, 3, 415CT16
Source	This ESR1/ER antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 246-273 amino acids from human ESR1/ER
Gene ID number	2099
Swiss Prot	P03372
Tested Applications	WB
Recommended dilutions	WB(1:100~250)
Cross reactivity	Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	ATF-2, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Can activate the transcriptional activity of TFF1, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3, Isoform 3 can bind to ERE and inhibit isoform 1, Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production, Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor, Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Sp1 and Sp3, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, c-Fos, such as AP-1/c-Jun, the function involves CREBBP, to mediate ERE-independent signaling, Nuclear hormone receptor
Purification method	This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	ER-alpha, ESR, ESR1, ESRA, ESTRR, Era, Estradiol receptor, Estrogen receptor, NR3A1, Nuclear receptor subfamily 3 group A member 1, ER
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About	Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target	1) Monoclonal, 2, 3, ESR1/ER (415CT16
Short name	1) Monoclonal Antibody, 2, 3, ESR1/ER (415CT16
Technique	Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name	1) monoclonal (Antibody to), 2, 3, ESR1/ER (415CT16
Alternative technique	antibodies
Identity	3467
Gene	ESR1
Long gene name	estrogen receptor 1
Synonyms gene	ESR
Synonyms	NR3A1 Era
Locus	6q25, 1-q25, 2
Discovery year	2001-06-22
GenBank acession	X03635
Entrez gene record	2099
Pubmed identfication	3754034
Classification	Nuclear hormone receptors
Havana BLAST/BLAT	OTTHUMG00000016103
Locus Specific Databases	LRG_992

ESR1/ER (415CT16.3.2.1) Monoclonal Antibody

ESR1/ER (415CT16.3.2.1) Monoclonal Antibody size: 0.1ml 211

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