| Long name | 5, 5) Monoclonal Antibody, ESR2 (555CT18 |
| Also known as | 5, 5) Monoclonal Antibody, ESR2 (555CT18 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ESR2 |
| Specificity | This is a highly specific antibody against ESR2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 5, 5, 555CT18 |
| Source | This ESR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the Central region of human ESR2 |
| Gene ID number | 2100 |
| Swiss Prot | Q92731 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:100~4000) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Binds estrogens with an affinity similar to that of ESR1, DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual, Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560), Nuclear hormone receptor |
| Purification method | 09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ER-BETA, ESR-BETA, ESR2, ESRB, ESTRB, Estrogen receptor beta, NR3A2, Nuclear receptor subfamily 3 group A member 2, Erb |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 5, 5) Monoclonal, ESR2 (555CT18 |
| Short name | 5, 5) Monoclonal Antibody, ESR2 (555CT18 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 5, 5) monoclonal (Antibody to), estrogen receptor 2 (ER beta) (555CT18 |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007420 and brain development and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008628 and hormone-mediated apoptotic signaling pathway and biological process this GO :0010467 and gene expression and biological process this GO :0019899 and enzyme binding and molecular function this GO :0030284 and estrogen receptor activity and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0030520 and intracellular estrogen receptor signaling pathway and biological process this GO :0034056 and estrogen response element binding and molecular function this GO :0042127 and regulation of cell proliferation and biological process this GO :0043401 and steroid hormone mediated signaling pathway and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0048019 and receptor anta this GO nist activity and molecular function this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0060065 and uterus development and biological process this GO :0060068 and vagina development and biological process this GO :0060740 and prostate gland epithelium morphogenesis and biological process this GO :0060743 and epithelial cell maturation involved in prostate gland development and biological process this GO :0060766 and negative regulation of androgen receptor signaling pathway and biological process this GO :1900116 and extracellular negative regulation of signal transduction and biological process, ER-BETA and Erb and ESR-BETA and ESRB and ESTRB and NR3A2, ESR2 and IDBG-646767 and ENSBTAG00000004498 and 281146, ESR2 and IDBG-9004 and ENSG00000140009 and 2100, Esr2 and IDBG-150083 and ENSMUSG00000021055 and 13983, nuclei, receptor anta this GO nist activity, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001046 and core promoter sequence-specific DNA binding and molecular function this GO :0001541 and ovarian follicle development and biological process this GO :0001764 and neuron migration and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003707 and steroid hormone receptor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0005496 and steroid binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0006351 and transcription, this GO :0001046: core promoter sequence-specific DNA binding, this GO :0001046: core promoter sequence-specific DNA binding and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003707: steroid hormone receptor activity and also this GO :0003713: transcription coactivator activity and also this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0005496: steroid binding and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0019899: enzyme binding and also this GO :0030284: estrogen receptor activity and also this GO :0034056: estrogen response element binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0048019: receptor anta this GO nist activity, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003707: steroid hormone receptor activity, this GO :0003713: transcription coactivator activity, this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0005496: steroid binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0019899: enzyme binding, this GO :0030284: estrogen receptor activity, this GO :0034056: estrogen response element binding, this GO :0043565: sequence-specific DNA binding, this GO :0048019: receptor anta this GO nist activity, estrogen receptor 2 (ER beta) |
| Identity | 3468 |
| Gene | ESR2 |
| Long gene name | estrogen receptor 2 |
| Synonyms gene name | estrogen receptor 2 (ER beta) |
| Synonyms | NR3A2 Erb |
| Synonyms name | ER beta |
| Locus | 14q23, 2-q23, 3 |
| Discovery year | 1997-01-17 |
| GenBank acession | X99101 |
| Entrez gene record | 2100 |
| Pubmed identfication | 8769313 |
| Classification | Nuclear hormone receptors |
| Havana BLAST/BLAT | OTTHUMG00000141306 |
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