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Estrogen Receptor alpha Antibody, Cy7 Conjugated

Estrogen Receptor alpha Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, Estrogen Receptor alpha Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenEstrogen Receptor alpha
SpecificityThis is a highly specific antibody against Estrogen Receptor alpha
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range310-360/600
Subcellular locationIntracellular
SourceKLH conjugated synthetic peptide derived from rat Estrogen Receptor alpha
Gene ID number24890
Swiss ProtP06211
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background ATF-2, Also mediates membrane-initiated estrogen signaling involving various kinase cascades, Can activate the transcriptional activity of TFF1, Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter, Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity), Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components, Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner, Present with NF-kappa-B components RELA/p65 and NFKB1/p5 on ERE sequences, Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP, Sp1 and Sp3, The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, c-Fos, such as AP-1/c-Jun, the function involves CREBBP, to mediate ERE-independent signaling, Nuclear hormone receptor
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms ER, ER-alpha, Esr1, Estr, Estradiol receptor, Estrogen receptor, Nr3a1, Nuclear receptor subfamily 3 group A member 1, RNESTROR, Esr
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetEstrogen Receptor alpha Conjugated
Short name Conjugated, Estrogen Receptor alpha Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, Estrogen Receptor a (Antibody to)
Alternative techniqueantibodies

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