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Exportin 1/CRM1 Antibody

Exportin 1/CRM1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameExportin 1/CRM1 Primary Polyclonal Antibody
Also known asExportin 1/CRM1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenExportin 1/CRM1
SpecificityThis is a highly specific antibody against Exportin 1/CRM1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range720-770/1071
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Exportin 1/CRM1
Gene ID number7514
Swiss ProtO14980
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds to late precursor U3 snoRNA bearing a TMG cap, Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus, In the nucleus, Interacts with, Involved in HTLV-1 Rex multimerization, Involved in U3 snoRNA transport from Cajal bodies to nucleoli, Several viruses, The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus, Upon transit of a nuclear export complex into the cytoplasm, among them HIV-1, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP), disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, in association with RANBP3, respectively) cause release of the cargo from the export receptor, Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CRM1, Chromosome region maintenance 1 protein homolog, Exportin-1, XPO1, exp1, emb
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetExportin 1/CRM1
Short nameExportin 1/CRM1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameExportin 1/CRM1 (Antibody to)
Alternative techniqueantibodies
Identity 12825
Gene XPO1
Long gene name exportin 1
Synonyms gene name exportin 1 (CRM1, homolog) exportin 1 (CRM1 homolog, yeast, yeast)
Synonyms CRM1 emb
Synonyms name chromosome region maintenance 1 homolog (yeast)
Locus 2p15
Discovery year 1998-05-12
GenBank acession Y08614
Entrez gene record 7514
Pubmed identfication 9205132 9368044
RefSeq identity NM_003400
Classification Exportins
Havana BLAST/BLAT OTTHUMG00000152316

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