| Long name | EYA1 Primary Polyclonal Antibody |
| Also known as | EYA1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | EYA1 |
| Specificity | This is a highly specific antibody against EYA1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 260-310/592 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EYA1 |
| Gene ID number | 2138 |
| Swiss Prot | Q99502 |
| Tested Applications | IF(IHC-P), IHC-P |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity | Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress, Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro), Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis, Required for normal embryonic development of the craniofacial and trunk skeleton, SIX4 and SIX5, Together with SIX1, Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1, and probably also for SIX2, in this it is functionally redundant with EYA2, it plays an important role in hypaxial muscle development, kidneys and ears, Functions both as protein phosphatase and as transcriptional coactivator for SIX1 |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | BOR, BOS1, EYA1, Eyes absent homolog 1, OFC1, BOP |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | EYA1 |
| Short name | EYA1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | eyes absent homolog 1 (Drosophila) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | BOP and BOR and BOS1 and OFC1, DNA-templated and biological process this GO :0006470 and protein dephosphorylation and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007389 and pattern specification process and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0009653 and anatomical structure morphogenesis and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0014706 and striated muscle tissue development and biological process this GO :0016576 and histone dephosphorylation and biological process this GO :0016925 and protein sumoylation and biological process this GO :0034613 and cellular protein localization and biological process this GO :0035088 and establishment or maintenance of apical/basal cell polarity and biological process this GO :0035335 and peptidyl-tyrosine dephosphorylation and biological process this GO :0035909 and aorta morphogenesis and biological process this GO :0042471 and ear morphogenesis and biological process this GO :0042472 and inner ear morphogenesis and biological process this GO :0042473 and outer ear morphogenesis and biological process this GO :0042474 and middle ear morphogenesis and biological process this GO :0045165 and cell fate commitment and biological process this GO :0045664 and regulation of neuron differentiation and biological process this GO :0045739 and positive regulation of DNA repair and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048665 and neuron fate specification and biological process this GO :0048704 and embryonic skeletal system morphogenesis and biological process this GO :0048752 and semicircular canal morphogenesis and biological process this GO :0048856 and anatomical structure development and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0060037 and pharyngeal system development and biological process this GO :0060487 and lung epithelial cell differentiation and biological process this GO :0071599 and otic vesicle development and biological process this GO :0071600 and otic vesicle morphogenesis and biological process this GO :0072513 and positive regulation of secondary heart field cardioblast proliferation and biological process this GO :0090103 and cochlea morphogenesis and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, EYA1 and IDBG-25014 and ENSG00000104313 and 2138, EYA1 and IDBG-644711 and ENSBTAG00000011298 and 511188, Eya1 and IDBG-134456 and ENSMUSG00000025932 and 14048, metal ion binding, nuclei, this GO :0000132 and establishment of mitotic spindle orientation and biological process this GO :0001656 and metanephros development and biological process this GO :0001657 and ureteric bud development and biological process this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0003151 and outflow tract morphogenesis and biological process this GO :0003723 and RNA binding and molecular function this GO :0004725 and protein tyrosine phosphatase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006302 and double-strand break repair and biological process this GO :0006351 and transcription, this GO :0003723: RNA binding, this GO :0003723: RNA binding and also this GO :0004725: protein tyrosine phosphatase activity and also this GO :0005515: protein binding and also this GO :0046872: metal ion binding, this GO :0004725: protein tyrosine phosphatase activity, this GO :0005515: protein binding, this GO :0046872: metal ion binding, eyes absent homolog 1 (Drosophila) |
| Identity | 3519 |
| Gene | EYA1 |
| Long gene name | EYA transcriptional coactivator and phosphatase 1 |
| Synonyms gene | BOR |
| Synonyms gene name | eyes absent (Drosophila) homolog 1 eyes absent homolog 1 (Drosophila) |
| Locus | 8q13, 3 |
| Discovery year | 1996-12-12 |
| GenBank acession | AJ000098 |
| Entrez gene record | 2138 |
| Pubmed identfication | 9020840 |
| RefSeq identity | NM_000503 NM_172060 |
| Classification | EYA transcriptional coactivator and phosphatases |
| Havana BLAST/BLAT | OTTHUMG00000149894 |
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