| Long name | FADD Primary Polyclonal Antibody |
| Also known as | FADD PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | FADD |
| Specificity | This is a highly specific antibody against FADD |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 10-60/205 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | KLH conjugated synthetic peptide derived from mouse FADD |
| Gene ID number | 14082 |
| Swiss Prot | Q61160 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity), Involved in interferon-mediated antiviral immune response, The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, playing a role in the positive regulation of interferon signaling (By similarity), Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | FAS-associated death domain protein, FAS-associating death domain-containing protein, Fadd, Mediator of receptor induced toxicity, Mort1, Protein FADD, Mort1/FADD |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | FADD |
| Short name | FADD Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | member 6) (TNFRSF6)-associated via death domain (Antibody to), Fas (TNF receptor superfamily |
| Alternative technique | antibodies |
| Alternative to gene target | FADD and IDBG-62144 and ENSG00000168040 and 8772, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, MORT1, Plasma membranes, alpha-beta cytotoxic T cell extravasation and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, identical protein binding, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002020 and protease binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0002821 and positive regulation of adaptive immune response and biological process this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016032 and viral process and biological process this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0032813 and tumor necrosis factor receptor superfamily binding and molecular function this GO :0033077 and T cell differentiation in thymus and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043029 and T cell homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048535 and lymph node development and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051607 and defense response to virus and biological process this GO :0060340 and positive regulation of type I interferon-mediated signaling pathway and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0070236 and negative regulation of activation-induced cell death of T cells and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0097049 and motor neuron apoptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097342 and ripoptosome and cellular component this GO :0097527 and necroptotic signaling pathway and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000454 and positive regulation of CD8-positive, this GO :0002020: protease binding, this GO :0002020: protease binding and also this GO :0005123: death receptor binding and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0032403: protein complex binding and also this GO :0032813: tumor necrosis factor receptor superfamily binding and also this GO :0035877: death effector domain binding and also this GO :0042802: identical protein binding, this GO :0005123: death receptor binding, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005515: protein binding, this GO :0032403: protein complex binding, this GO :0032813: tumor necrosis factor receptor superfamily binding, this GO :0035877: death effector domain binding, this GO :0042802: identical protein binding, Fas (TNFRSF6)-associated via death domain |
| Identity | 3573 |
| Gene | FADD |
| Long gene name | Fas associated via death domain |
| Synonyms gene name | Fas (TNFRSF6)-associated via death domain |
| Synonyms | MORT1 GIG3 |
| Synonyms name | Fas-associating protein with death domain Fas-associating death domain-containing protein mediator of receptor-induced toxicity growth-inhibiting gene 3 protein |
| Locus | 11q13, 3 |
| Discovery year | 1999-05-07 |
| GenBank acession | U24231 |
| Entrez gene record | 8772 |
| Pubmed identfication | 7536190 7538907 |
| RefSeq identity | NM_003824 |
| Classification | Death effector domain containing Ripoptosome Death inducing signaling complex |
| Havana BLAST/BLAT | OTTHUMG00000167264 |
| Locus Specific Databases | LRG_228 |
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