Filters

FAK(Tyr861) Antibody

FAK(Tyr861) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFAK(Tyr861) Primary Polyclonal Antibody
Also known asFAK(Tyr861) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFAKTyr861
Specificity This phosphorylation site is homologous to Tyr899 in Mouse and Tyr861 in Rat, This is a highly specific antibody against FAKTyr861
Modification(s)Phosphorylation
Modification site(s)Tyr861
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range840-890/1052
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human FAK around the phosphorylation site of Tyr861
Gene ID number5747
Swiss ProtQ05397
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ARHGEF7, EPHA2, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in integrin signal transduction, G-protein coupled receptors (GPCR), GRB7, MAPK3/ERK1 and the MAP kinase signaling cascade, P53/TP53 ubiquitination and proteasomal degradation, Phosphorylates ACTN1, Phosphorylates SRC, Plays a role in osteogenesis and differentiation of osteoblasts, Promotes activation of MAPK1/ERK2, Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade, Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), RET and WASL, Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates axon growth and neuronal cell migration, Regulates numerous signaling pathways, Required for early embryonic development and placenta development, Required for embryonic angiogenesis, Signaling via CAS family members mediates activation of RAC1, adhesion, and normal heart development, and thereby modulates the activity of Rho family GTPases, and thereby regulates P53/TP53 activity, axon branching and synapse formation, but also in signaling downstream of numerous growth factor receptors, cell cycle progression, cell proliferation and apoptosis, creating binding sites for scaffold proteins, effectors and substrates, formation and disassembly of focal adhesions and cell protrusions, netrin receptors and LDL receptors, normal cardiomyocyte migration and proliferation, reorganization of the actin cytoskeleton, required for normal development of the nervous system, spreading, this increases SRC kinase activity, this leads to the phosphorylation of additional tyrosine residues, Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FADK, FADK 1, FAK1, FRNK, Focal adhesion kinase 1, Focal adhesion kinase-related nonkinase, PPP1R71, PTK2, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FAK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFAK(Tyr861)
Short nameFAK(Tyr861) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFAK(Tyr861) (Antibody to)
Alternative techniqueantibodies
Identity 9611
Gene PTK2
Long gene name protein tyrosine kinase 2
Synonyms gene name PTK2 protein tyrosine kinase 2
Synonyms FAK FADK FAK1 PPP1R71
Synonyms name protein phosphatase 1, regulatory subunit 71
Locus 8q24, 3
Discovery year 1992-10-02
GenBank acession L13616
Entrez gene record 5747
Pubmed identfication 8422239
RefSeq identity NM_005607
Classification Protein phosphatase 1 regulatory subunits FERM domain containing
Havana BLAST/BLAT OTTHUMG00000067438

Similar products

Subscribe to our Newsletter