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FAK(Tyr861) Antibody, ALEXA FLUOR 647

FAK(Tyr861) Antibody, ALEXA FLUOR 647 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 647 Conjugated, FAK(Tyr861) Polyclonal Antibody
Also known asAnti-FAKTyr861 PAb ALEXA FLUOR 647
CategoryConjugated Primary Antibodies
Conjugated with 647, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFAKTyr861
SpecificityThis is a highly specific antibody against FAKTyr861
ModificationPhosphorylation
Modification SiteTyr861
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range840-890/1052
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human FAK around the phosphorylation site of Tyr861
Gene ID Number5747
Swiss ProtQ05397
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen ARHGEF7, EPHA2, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in integrin signal transduction, G-protein coupled receptors (GPCR), GRB7, MAPK3/ERK1 and the MAP kinase signaling cascade, P53/TP53 ubiquitination and proteasomal degradation, Phosphorylates ACTN1, Phosphorylates SRC, Plays a role in osteogenesis and differentiation of osteoblasts, Promotes activation of MAPK1/ERK2, Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade, Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), RET and WASL, Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates axon growth and neuronal cell migration, Regulates numerous signaling pathways, Required for early embryonic development and placenta development, Required for embryonic angiogenesis, Signaling via CAS family members mediates activation of RAC1, adhesion, and normal heart development, and thereby modulates the activity of Rho family GTPases, and thereby regulates P53/TP53 activity, axon branching and synapse formation, but also in signaling downstream of numerous growth factor receptors, cell cycle progression, cell proliferation and apoptosis, creating binding sites for scaffold proteins, effectors and substrates, formation and disassembly of focal adhesions and cell protrusions, netrin receptors and LDL receptors, normal cardiomyocyte migration and proliferation, reorganization of the actin cytoskeleton, required for normal development of the nervous system, spreading, this increases SRC kinase activity, this leads to the phosphorylation of additional tyrosine residues, Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission650nm/665nm
Synonyms FAK FADK FAK1 PPP1R71
Properties ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the FAK(Tyr861) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 647, Alexa Fluor
Gene targetFAK(Tyr861)
Short nameFAK(Tyr861) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 647
Alternative name ALEXA FLUOR 647, FAK(Tyr861) (Antibody to)
Alternative techniqueantibodies
Identity 9611
Gene PTK2
Long gene name protein tyrosine kinase 2
Synonyms gene name PTK2 protein tyrosine kinase 2
Synonyms name protein phosphatase 1, regulatory subunit 71
Locus 8q24, 3
Discovery year 1992-10-02
GenBank acession L13616
Entrez gene record 5747
Pubmed identfication 8422239
RefSeq identity NM_005607
Classification Protein phosphatase 1 regulatory subunits FERM domain containing
Havana BLAST/BLAT OTTHUMG00000067438

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