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FAK1 (1D10) Monoclonal Antibody

FAK1 (1D10) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFAK1 (1D10) Monoclonal Antibody
Also known asFAK1 (1D10) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFAK1
SpecificityThis is a highly specific antibody against FAK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1D10
Concentration2ug/ul
Source 1-421 a, ), Recombinant human protein purified from E, a, coli(His-FAK1
Gene ID number5747
Swiss ProtQ05397
Tested Applications IP, WB
Recommended dilutions0 ug), 0 ug/mL) IP (2, WB (2
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen FAK is a nonreceptor and nonmembrane associated PTK which does not contain Src homology 2 (SH2) or SH3 protein interaction domains, FAK links integrin receptors to intracellular signaling pathways that are important for cell growth, Integrin receptor engagement with ligands such as fibronectin can stimulate FAK autophosphorylation which enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways, Recent study reveals that FAK is essential for angiogenesis in the embryo, The centrally located kinase domain of FAK is flanked by large N- and C-terminal noncatalytic domains, The presence of two proline-rich motifs within the C-terminal domains is conserved, These two kinases have molecular mass between 110-125 kDa and are closely related in their structure, Two members of the family are focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2), and migration, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice, survival, Focal adhesion kinase subfamily consists of the non-receptor proline-rich protein tyrosine kinases (PTKs)
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FADK, FADK 1, FAK1, FRNK, Focal adhesion kinase 1, Focal adhesion kinase-related nonkinase, PPP1R71, PTK2, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FAK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetFAK1 (1D10) Monoclonal
Short nameFAK1 (1D10) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameFAK1 (1D10) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 9611
Gene PTK2
Long gene name protein tyrosine kinase 2
Synonyms gene name PTK2 protein tyrosine kinase 2
Synonyms FAK FADK FAK1 PPP1R71
Synonyms name protein phosphatase 1, regulatory subunit 71
Locus 8q24, 3
Discovery year 1992-10-02
GenBank acession L13616
Entrez gene record 5747
Pubmed identfication 8422239
RefSeq identity NM_005607
Classification Protein phosphatase 1 regulatory subunits FERM domain containing
Havana BLAST/BLAT OTTHUMG00000067438

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