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FAK2/PYK2 Antibody

FAK2/PYK2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFAK2/PYK2 Primary Polyclonal Antibody
Also known asFAK2/PYK2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFAK2/PYK2
SpecificityThis is a highly specific antibody against FAK2/PYK2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range20-70/1009
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FAK2/Pyk2
Gene ID number2185
Swiss ProtQ14289
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen 'Tyr-373', Acts as a scaffold, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in signaling downstream of integrin and collagen receptors, G-protein coupled receptors (GPCR), MAPK3/ERK1 and MAPK8/JNK1, May inhibit differentiation and activity of osteoprogenitor cells, P53/TP53 ubiquitination and proteasomal degradation, Plays a role in the regulation of the humoral immune response, Promotes activation of Rho family GTPases, Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade, Promotes activation of the MAP kinase signaling cascade, Promotes osteoclastic bone resorption, Promotes phosphorylation of NMDA receptors by SRC family members, Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates cytoskeleton rearrangement and cell spreading in T-cells, Regulates numerous signaling pathways, Regulates production of the cellular messenger cGMP, Required for normal macrophage polarization and migration towards sites of inflammation, adhesion, and 'Tyr-376', and contributes to the regulation of T-cell responses, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells, and mediates responses to cellular stress, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels, and thereby regulates P53/TP53 activity, binding to both PDPK1 and SRC, cell migration, cell polarization, chemokine and growth factor receptors, creating binding sites for scaffold proteins, cytokine, effectors and substrates, immune receptors, including activation of MAPK1/ERK2, spreading and bone remodeling, such as RHOA and RAC1, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, this leads to the phosphorylation of additional tyrosine residues, this requires both PTK2B/PYK2 and SRC, Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CADTK, CAK-beta, CAKB, Calcium-dependent tyrosine kinase, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, FADK 2, FADK2, FAK2, Focal adhesion kinase 2, PTK, PTK2B, PYK2, Proline-rich tyrosine kinase 2, Protein-tyrosine kinase 2-beta, RAFTK, Related adhesion focal tyrosine kinase, PKB
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFAK2/PYK2
Short nameFAK2/PYK2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFAK2/PYK2 (Antibody to)
Alternative techniqueantibodies
Identity 9612
Gene PTK2B
Long gene name protein tyrosine kinase 2 beta
Synonyms gene FAK2
Synonyms gene name protein tyrosine kinase 2 beta PTK2B protein tyrosine kinase 2 beta
Synonyms CAKB PYK2 RAFTK PTK CADTK
Locus 8p21, 2
Discovery year 1998-06-22
GenBank acession U33284
Entrez gene record 2185
Pubmed identfication 7544443 7499242
RefSeq identity NM_004103
Classification Minor histocompatibility antigens FERM domain containing
Havana BLAST/BLAT OTTHUMG00000102082

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