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FAK2/PYK2 Antibody, Cy3 Conjugated

FAK2/PYK2 Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, FAK2/PYK2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFAK2/PYK2
SpecificityThis is a highly specific antibody against FAK2/PYK2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range20-70/1009
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human FAK2/Pyk2
Gene ID number2185
Swiss ProtQ14289
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background 'Tyr-373', Acts as a scaffold, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in signaling downstream of integrin and collagen receptors, G-protein coupled receptors (GPCR), MAPK3/ERK1 and MAPK8/JNK1, May inhibit differentiation and activity of osteoprogenitor cells, P53/TP53 ubiquitination and proteasomal degradation, Plays a role in the regulation of the humoral immune response, Promotes activation of Rho family GTPases, Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade, Promotes activation of the MAP kinase signaling cascade, Promotes osteoclastic bone resorption, Promotes phosphorylation of NMDA receptors by SRC family members, Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates cytoskeleton rearrangement and cell spreading in T-cells, Regulates numerous signaling pathways, Regulates production of the cellular messenger cGMP, Required for normal macrophage polarization and migration towards sites of inflammation, adhesion, and 'Tyr-376', and contributes to the regulation of T-cell responses, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells, and mediates responses to cellular stress, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels, and thereby regulates P53/TP53 activity, binding to both PDPK1 and SRC, cell migration, cell polarization, chemokine and growth factor receptors, creating binding sites for scaffold proteins, cytokine, effectors and substrates, immune receptors, including activation of MAPK1/ERK2, spreading and bone remodeling, such as RHOA and RAC1, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, this leads to the phosphorylation of additional tyrosine residues, this requires both PTK2B/PYK2 and SRC, Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms CAKB PYK2 RAFTK PTK CADTK
Properties 1 of the FAK2/PYK2 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetFAK2/PYK2 Conjugated
Short name Conjugated, FAK2/PYK2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, FAK2/PYK2 (Antibody to)
Alternative techniqueantibodies
Identity 9612
Gene PTK2B
Long gene name protein tyrosine kinase 2 beta
Synonyms gene FAK2
Synonyms gene name protein tyrosine kinase 2 beta PTK2B protein tyrosine kinase 2 beta
Locus 8p21, 2
Discovery year 1998-06-22
GenBank acession U33284
Entrez gene record 2185
Pubmed identfication 7544443 7499242
RefSeq identity NM_004103
Classification Minor histocompatibility antigens FERM domain containing
Havana BLAST/BLAT OTTHUMG00000102082

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