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FAN1 Antibody

FAN1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFAN1 Primary Polyclonal Antibody
Also known asFAN1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFAN1
SpecificityThis is a highly specific antibody against FAN1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range400-450/1017
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FAN1
Gene ID number22909
Swiss ProtQ9Y2M0
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771), Also has endonuclease activity toward 5'-flaps (PubMed:20603015, Not involved in DNA double-strand breaks resection (PubMed:20603015, Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771), PubMed:20603016, PubMed:20603016, PubMed:20603016), PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:24981866), PubMed:25430771), Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, allowing to excise an ICL from one strand through flanking incisions, probably in the resolution of homologous recombination intermediates (PubMed:20603015, Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FAN1, FANCD2/FANCI-associated nuclease 1, Fanconi-associated nuclease 1, KIAA1018, MTMR15, Myotubularin-related protein 15, hFAN1, KMIN
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFAN1
Short nameFAN1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFANCD2/FANCI-associated nuclease 1 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target DNA incision and biological process this GO :0043130 and ubiquitin binding and molecular function, FAN1 and IDBG-4900 and ENSG00000198690 and 22909, FAN1 and IDBG-630438 and ENSBTAG00000009855 and 508171, Fan1 and IDBG-191028 and ENSMUSG00000033458 and 330554, KIAA1018 and KMIN and MTMR15, acting on ester bonds, acting on ester bonds and also this GO :0017108: 5'-flap endonuclease activity and also this GO :0043130: ubiquitin binding, acting on ester bonds and molecular function this GO :0017108 and 5'-flap endonuclease activity and molecular function this GO :0033683 and nucleotide-excision repair, endonucleolytic and biological process this GO :0003677 and DNA binding and molecular function this GO :0004528 and phosphodiesterase I activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006281 and DNA repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0008409 and 5'-3' exonuclease activity and molecular function this GO :0016788 and hydrolase activity, hydrolase activity, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0000737 and DNA catabolic process, this GO :0000287: magnesium ion binding, this GO :0000287: magnesium ion binding and also this GO :0003677: DNA binding and also this GO :0004528: phosphodiesterase I activity and also this GO :0005515: protein binding and also this GO :0008409: 5'-3' exonuclease activity and also this GO :0016788: hydrolase activity, this GO :0003677: DNA binding, this GO :0004528: phosphodiesterase I activity, this GO :0005515: protein binding, this GO :0008409: 5'-3' exonuclease activity, this GO :0016788: hydrolase activity, this GO :0017108: 5'-flap endonuclease activity, this GO :0043130: ubiquitin binding, FANCD2/FANCI-associated nuclease 1
Identity 29170
Gene FAN1
Long gene name FANCD2 and FANCI associated nuclease 1
Synonyms gene KIAA1018 MTMR15
Synonyms gene name KIAA1018 myotubularin related protein 15 FANCD2/FANCI-associated nuclease 1
Locus 15q13, 3
Discovery year 2005-10-28
Entrez gene record 22909
Pubmed identfication 20603015 20603016 20603073
RefSeq identity NM_014967
Havana BLAST/BLAT OTTHUMG00000175661

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