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FAT10 Antibody

FAT10 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration09% sodium azide, 4 with 0, In 1X PBS pH 7
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenFAT10
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus)
Tested applications ELISA, IF, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the FAT10 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis FAT10 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O15205
PurityAntigen affinity
Description Conjugation ability activated by UBA6, May be involved in dendritic cell (DC) maturation, May be involved in the formation of aggresomes when proteasome is saturated or impaired, Mediates apoptosis in a caspase-dependent manner, Mediates mitotic non-disjunction and chromosome instability, Probably functions as a survival factor, Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2), Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha, Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs), [UniProt], by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN), in a NUB1L-dependent manner, in long-term in vitro culture and cancers, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses, FAT10/UBD is a Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome
ImmunogenA portion of amino acids 120-153 from the human protein was used as the immunogen for this FAT10 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the FAT10 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetFAT10
Short nameFAT10 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFAT10 (Antibody to)
Alternative techniqueantibodies
Identity 18795
Gene UBD
Long gene name ubiquitin D
Synonyms FAT10
Locus 6p22, 1
Discovery year 2002-06-19
GenBank acession Y12653
Entrez gene record 10537
Pubmed identfication 9368598 8662070
Havana BLAST/BLAT OTTHUMG00000031289

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