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FBXO11 Antibody, Biotin Conjugated

FBXO11 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, FBXO11 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFBXO11
SpecificityThis is a highly specific antibody against FBXO11
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range85-127/927
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human FBXO11
Gene ID number80204
Swiss ProtQ86XK2
Tested applicationsIHC-P
Recommended dilutionsIHC-P(1:100-500)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background BCL6 and PRDM1/BLIMP1, Binds to and neddylates phosphorylated p53/TP53, SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53, The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit, inhibiting its transcriptional activity, such as DTL/CDT2, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells, Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms FBX11 UBR6
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetFBXO11 Conjugated
Short name Conjugated, FBXO11 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, FBXO11 (Antibody to)
Alternative techniqueantibodies
Identity 13590
Gene FBXO11
Long gene name F-box protein 11
Synonyms gene name F-box only protein 11
Synonyms name ubiquitin protein ligase E3 component n-recognin 6
Locus 2p16, 3
Discovery year 2000-09-27
GenBank acession AF174599
Entrez gene record 80204
Pubmed identfication 10531035 16487488 18162545
RefSeq identity NM_012167 NM_018693 NM_025133
Classification F-boxes other Ubiquitin protein ligase E3 component n-recognins
Havana BLAST/BLAT OTTHUMG00000129130

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