| Long name | 23) Monoclonal Antibody, 50, FGFR1 (1440CT772 |
| Also known as | 23) Monoclonal Antibody, 50, FGFR1 (1440CT772 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | FGFR1 |
| Specificity | This is a highly specific antibody against FGFR1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1440CT772, 23, 50 |
| Source | This FGFR1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 806-842 amino acids from the C-terminal region of human FGFR1 |
| Gene ID number | 2260 |
| Swiss Prot | P11362 |
| Tested Applications | IF, IHC-P, WB |
| Recommended dilutions | IF(1:25), IHC-P(1:25), WB(1:2000) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR1 signaling is down-regulated by IL17RD/SEF, FRS2, GAB1, GAB1 and SHB, In the nucleus, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, PIK3R1 and SOS1, Phosphorylates PLCG1, Phosphorylation of FRS2 triggers recruitment of GRB2, Promotes phosphorylation of SHC1, Required for normal mesoderm patterning and correct axial organization during embryonic development, STAT1 and PTPN11/SHP2, and by FGFR1 ubiquitination, and mediates activation of RAS, as well as of the AKT1 signaling pathway, cell proliferation, differentiation and migration, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription, internalization and degradation, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | BFGFR, Basic fibroblast growth factor receptor 1, CD331, ECCL, FGFBR, FGFR-1, FGFR1, FLG, FLT-2, FLT2, Fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, Proto-oncogene c-Fgr, bFGF-R-1, CEK |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 23) Monoclonal, 50, FGFR1 (1440CT772 |
| Short name | 23) Monoclonal Antibody, 50, FGFR1 (1440CT772 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 23) monoclonal (Antibody to), 50, fibroblast growth factor receptor 1 (1440CT772 |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007411 and axon guidance and biological process this GO :0007420 and brain development and biological process this GO :0007435 and salivary gland morphogenesis and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0008201 and heparin binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010518 and positive regulation of phospholipase activity and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0010863 and positive regulation of phospholipase C activity and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016477 and cell migration and biological process this GO :0016772 and transferase activity, FGFR1 and IDBG-17796 and ENSG00000077782 and 2260, FGFR1 and IDBG-629273 and ENSBTAG00000015457 and 281768, Fgfr1 and IDBG-143767 and ENSMUSG00000031565 and 14182, bFGF-R-1 and BFGFR and CD331 and CEK and FGFBR and FGFR-1 and FLG and FLT-2 and FLT2 and HBGFR and HH2 and HRTFDS and KAL2 and N-SAM and OGD, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000165 and MAPK cascade and biological process this GO :0001501 and skeletal system development and biological process this GO :0001525 and angiogenesis and biological process this GO :0001657 and ureteric bud development and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001759 and organ induction and biological process this GO :0001764 and neuron migration and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0002062 and chondrocyte differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005007 and fibroblast growth factor-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006351 and transcription, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005007: fibroblast growth factor-activated receptor activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008201: heparin binding and also this GO :0016772: transferase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005007: fibroblast growth factor-activated receptor activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008201: heparin binding, this GO :0016772: transferase activity, this GO :0017134: fibroblast growth factor binding, this GO :0042802: identical protein binding, this GO :0042803: protein homodimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017134: fibroblast growth factor binding and also this GO :0042802: identical protein binding and also this GO :0042803: protein homodimerization activity, transferring phosphorus-containing groups and molecular function this GO :0017134 and fibroblast growth factor binding and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0021769 and orbitofrontal cortex development and biological process this GO :0021847 and ventricular zone neuroblast division and biological process this GO :0030324 and lung development and biological process this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0030901 and midbrain development and biological process this GO :0035607 and fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042472 and inner ear morphogenesis and biological process this GO :0042473 and outer ear morphogenesis and biological process this GO :0042474 and middle ear morphogenesis and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043009 and chordate embryonic development and biological process this GO :0043235 and receptor complex and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0045087 and innate immune response and biological process this GO :0045595 and regulation of cell differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045787 and positive regulation of cell cycle and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048339 and paraxial mesoderm development and biological process this GO :0048378 and regulation of lateral mesodermal cell fate specification and biological process this GO :0048469 and cell maturation and biological process this GO :0048514 and blood vessel morphogenesis and biological process this GO :0048699 and generation of neurons and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0048762 and mesenchymal cell differentiation and biological process this GO :0060045 and positive regulation of cardiac muscle cell proliferation and biological process this GO :0060117 and auditory receptor cell development and biological process this GO :0060445 and branching involved in salivary gland morphogenesis and biological process this GO :0060484 and lung-associated mesenchyme development and biological process this GO :0060665 and regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling and biological process this GO :0090080 and positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, fibroblast growth factor receptor 1 |
| Identity | 3688 |
| Gene | FGFR1 |
| Long gene name | fibroblast growth factor receptor 1 |
| Synonyms gene | FLT2 KAL2 |
| Synonyms gene name | fms-related tyrosine kinase 2 |
| Synonyms | H2 H3 H4 H5 CEK FLG BFGFR N-SAM CD331 |
| Synonyms name | Pfeiffer syndrome |
| Locus | 8p11, 23 |
| Discovery year | 1992-02-25 |
| GenBank acession | M34185 |
| Entrez gene record | 2260 |
| Pubmed identfication | 2162671 |
| Classification | I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT | OTTHUMG00000147366 |
| Locus Specific Databases | LRG_993 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue