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FGFR2 Antibody, ALEXA FLUOR 488

FGFR2 Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, FGFR2 Polyclonal Antibody
Also known asAnti-FGFR2 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFGFR2
SpecificityThis is a highly specific antibody against FGFR2
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FGFR2
Gene ID Number2263
Swiss ProtP21802
Tested applicationsFCM
Recommended dilutionsFCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR2 signaling is down-regulated by ubiquitination, FRS2 and PAK4, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, Over-expressed FGFR2 promotes activation of STAT1, PIK3R1 and SOS1, Phosphorylates PLCG1, Phosphorylation of FRS2 triggers recruitment of GRB2, Plays an essential role in the regulation of osteoblast differentiation, Promotes cell proliferation in keratinocytes and immature osteoblasts, Required for normal embryonic patterning, and in the regulation of embryonic development, and is required for normal skeleton development, and mediates activation of RAS, as well as of the AKT1 signaling pathway, but promotes apoptosis in differentiated osteoblasts, differentiation, internalization and degradation, internalization and degradation lead to aberrant signaling, limb bud development, lung morphogenesis, migration and apoptosis, osteogenesis and skin development, proliferation and apoptosis, trophoblast function, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms CEK3 TK14 TK25 ECT1 K-SAM CD332
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the FGFR2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetFGFR2
Short nameFGFR2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, FGFR2 (Antibody to)
Alternative techniqueantibodies
Identity 3689
Gene FGFR2
Long gene name fibroblast growth factor receptor 2
Synonyms gene KGFR BEK CFD1 JWS
Synonyms gene name bacteria-expressed kinase keratinocyte growth factor receptor craniofacial dysostosis 1 Jackson-Weiss syndrome
Synonyms name Crouzon syndrome Pfeiffer syndrome
Locus 10q26, 13
Discovery year 1991-05-09
GenBank acession AK026508
Entrez gene record 2263
RefSeq identity NM_022976 NM_000141
Classification I-set domain containing CD molecules Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000019175
Locus Specific Databases LRG_994

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