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FGFR4/CD334 Antibody, ALEXA FLUOR 555

FGFR4/CD334 Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, FGFR4/CD334 Polyclonal Antibody
Also known asAnti-FGFR4/CD334 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFGFR4/CD334
SpecificityThis is a highly specific antibody against FGFR4/CD334
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range40-90/762
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FGFR4
Gene ID Number2264
Swiss ProtP22455
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR4 signaling is down-regulated by receptor internalization and degradation, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, MMP14 promotes internalization and degradation of FGFR4, Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling, PIK3R1 and SOS1, Phosphorylates PLCG1 and FRS2, Phosphorylation of FRS2 triggers recruitment of GRB2, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, Required for normal down-regulation of the expression of CYP7A1, and in regulation of lipid metabolism, and mediates activation of RAS, as well as of the AKT1 signaling pathway, bile acid biosynthesis, differentiation and migration, glucose uptake, in response to FGF19, the rate-limiting enzyme in bile acid synthesis, vitamin D metabolism and phosphate homeostasis, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms JTK2 CD334
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetFGFR4/CD334
Short nameFGFR4/CD334 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, FGFR4/CD334 (Antibody to)
Alternative techniqueantibodies
Identity 3691
Gene FGFR4
Long gene name fibroblast growth factor receptor 4
Locus 5q35, 2
Discovery year 1991-07-25
GenBank acession AF202063
Entrez gene record 2264
Classification I-set domain containing CD molecules Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000151523

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