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FHIT (1093CT23.1.2) Monoclonal Antibody

FHIT (1093CT23.1.2) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name1, 2) Monoclonal Antibody, FHIT (1093CT23
Also known as1, 2) Monoclonal Antibody, FHIT (1093CT23
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFHIT
SpecificityThis is a highly specific antibody against FHIT
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1, 1093CT23, 2
SourceThis FHIT antibody is generated from a mouse immunized with a recombinant protein
Gene ID number2272
Swiss ProtP49789
Tested Applications FCM, WB
Recommended dilutions WB(1:4000), FC(1:25)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), Functions as tumor suppressor, Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis, Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways, but does not require its catalytic activity, but has extremely low activity with ATP, enhancing mitochondrial calcium uptake, it may in part come from the mitochondrial form, such as CCND1 and BIRC5, which sensitizes the low-affinity Ca(2+) transporters, Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AP3A hydrolase, AP3Aase, Bis(5'-adenosyl)-triphosphatase, Diadenosine 5', Dinucleosidetriphosphatase, FHIT, Fragile histidine triad protein, 5'''-P1, FRA3B, P3-triphosphate hydrolase
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target1, 2) Monoclonal, FHIT (1093CT23
Short name1, 2) Monoclonal Antibody, FHIT (1093CT23
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name1, 2) monoclonal (Antibody to), FHIT (1093CT23
Alternative techniqueantibodies
Identity 3701
Gene FHIT
Long gene name fragile histidine triad
Synonyms gene name fragile histidine triad gene
Synonyms FRA3B AP3Aase
Locus 3p14, 2
Discovery year 1996-10-18
GenBank acession BC032336
Entrez gene record 2272
Pubmed identfication 8598045 9671749 26181368
RefSeq identity NM_002012
Havana BLAST/BLAT OTTHUMG00000158591

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