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FHIT (Tyr114) Antibody, Cy7 Conjugated

FHIT (Tyr114) Antibody, Cy7 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, FHIT (Tyr114) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFHIT Tyr114
SpecificityThis is a highly specific antibody against FHIT Tyr114
ModificationPhosphorylation
Modification siteTyr114
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range90-130/147
Subcellular location Mitochondrion, Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human FHIT around the phosphorylation site of Tyr114
Gene ID number2272
Swiss ProtP49789
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), Functions as tumor suppressor, Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis, Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways, but does not require its catalytic activity, but has extremely low activity with ATP, enhancing mitochondrial calcium uptake, it may in part come from the mitochondrial form, such as CCND1 and BIRC5, which sensitizes the low-affinity Ca(2+) transporters, Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms FRA3B AP3Aase
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetFHIT (Tyr114) Conjugated
Short name Conjugated, FHIT (Tyr114) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, FHIT (Tyr114) (Antibody to)
Alternative techniqueantibodies
Identity 3701
Gene FHIT
Long gene name fragile histidine triad
Synonyms gene name fragile histidine triad gene
Locus 3p14, 2
Discovery year 1996-10-18
GenBank acession BC032336
Entrez gene record 2272
Pubmed identfication 8598045 9671749 26181368
RefSeq identity NM_002012
Havana BLAST/BLAT OTTHUMG00000158591

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