| Alternative name1 | CASH, CASH, CASP8 and FADD-like Apoptosis Regulator, CASP8AP1, CFLAR, CLARP, CLARP, Caspase Homolog, Caspase-eight-related Protein, Caspase-like Apoptosis Regulatory Protein, Casper, Cellular FLICE-li, MRIT, Anti-FLIP-L (FLICE-like Inhibitory Protein Long Form |
| Alternative name2 | CASH, CASH, CASP8 and FADD-like Apoptosis Regulator, CASP8AP1, CFLAR, CLARP, CLARP, Caspase Homolog, Caspase-eight-related Protein, Caspase-like Apoptosis Regulatory Protein, Casper, Cellular FLICE-li, MRIT, FLIP-L (FLICE-like Inhibitory Protein Long Form |
| Alternative name3 | CASH, CASH, CASP8 and FADD-like Apoptosis Regulator, CASP8AP1, CFLAR, CLARP, CLARP, Caspase Homolog, Caspase-eight-related Protein, Caspase-like Apoptosis Regulatory Protein, Casper, Cellular FLICE-li, MRIT, FLIP-L (FLICE-like Inhibitory Protein Long Form |
| Alternative name4 | FLIP-L |
| Alternative name5 | CASH, CASH, CASP8 and FADD-like Apoptosis Regulator, CASP8AP1, CFLAR, CLARP, CLARP, Caspase Homolog, Caspase-eight-related Protein, Caspase-like Apoptosis Regulatory Protein, Casper, Cellular FLICE-li, MRIT, Anti -FLIP-L (FLICE-like Inhibitory Protein Long Form |
| Other names | Fas apoptotic inhibitory molecule 3, Fas apoptotic inhibitory molecule 3, Fc mu receptor, IgM Fc receptor, Regulator of Fas-induced apoptosis Toso, fas apoptotic inhibitory molecule 3, immunoglobulin mu Fc receptor, regulator of Fas-induced apoptosis Toso, fas apoptotic inhibitory molecule 3 isoform c |
| Gene name | N/A |
| Gene name synonims | N/A |
| Other gene names | FAIM3, FCMR, TOSO, TOSO, FAIM3 |
| Category | Antibodies |
| Clonality | Polyclonal |
| Immunoglobulin isotype | IgG |
| Clone | Polyclonal antibody |
| Host organism | Source: Human, Host: Rabbit |
| Species reactivity | Mouse, Rat, Human |
| Specificity and cross-reactivity | Species Cross-Reactivity: mouse, rat, Recognizes human FLIP-L |
| Purification method | Affinity Purified by immunoaffinity chromatography |
| Form/Appearance | 0, 0, 5% BSA, Reconstitute with 200ul sterile ddH2O, pH 7, 05% sodium azide, 05% thimerosal, 4, Supplied as a lyophilized powder from PBS |
| Concentration | N/A |
| Storage and shipping | Aliquot to avoid repeated freezing and thawing, For maximum recovery of product, For optimal long term storage, Further dilutions can be made in assay buffer, Reconstitute with sterile ddH2O, Reconstituted product is stable for 12 months productone should be stored at -20 degrees Celsius, Stable for 12 months productone should be stored at -20 degrees Celsius, centrifuge the original vial after thawing and prior to removing the cap, productone should be kept at -20 degrees Celsius, Lyophilized powder may be stored productone should be stored at -20 degrees Celsius |
| Tested for: | Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
| Description | Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target | CASH, CASH, CASP8 FADD-like Regulator, CASP8AP1, CFLAR, CLARP, CLARP, Caspase Homolog, Caspase-eight-related Protein, Caspase-like Regulatory Protein, Casper, Cellular FLICE-li, MRIT, FLIP-L (FLICE-like Inhibitory Protein Long Form |
| Short name | CASH, CASH, CASP8 FADD-like Apoptosis Regulator, CASP8AP1, CFLAR, CLARP, CLARP, Caspase Homolog, Caspase-eight-related Protein, Caspase-like Apoptosis Regulatory Protein, Casper, Cellular FLICE-li Antibody, MRIT, FLIP-L (FLICE-like Inhibitory Protein Long Form |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | CASH, CASH, CASP8 and Fas (TNF receptor superfamily, CASP8AP1, CLARP, CLARP, Casper, Cellular FLICE-li (Antibody to), MRIT, apoptosis-related cysteine peptidase and Fas (TNF receptor superfamily, caspase 8, caspase Homolog, caspase-eight-related Protein, caspase-like programmed cellular destruction Regulatory Protein, member 6) (TNFRSF6)-associated via death domain-like apoptosis regulator, member 6) (TNFRSF6)-associated via death domain-like programmed cellular destruction Regulator, FLIP-L (FLICE-like Inhibitory Protein large Form |
| Alternative technique | antibodies |
| Alternative to gene target | ALPS2B and CAP4 and Casp-8 and FLICE and MACH and MCH5, CASP8 and FADD-like apoptosis regulator, CASP8 and IDBG-643207 and ENSBTAG00000015718 and 507481, CASP8 and IDBG-78534 and ENSG00000064012 and 841, CFLAR and IDBG-78386 and ENSG00000003402 and 8837, Casp8 and IDBG-157464 and ENSMUSG00000026029 and 12370, FADD and IDBG-62144 and ENSG00000168040 and 8772, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720, FLIP and IDBG-643202 and ENSBTAG00000010998 and 497199, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, MORT1, Plasma membranes, Plasma membranes, alpha-beta cytotoxic T cell extravasation and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, apoptosis-related cysteine peptidase, c-FLIP and c-FLIPL and c-FLIPR and c-FLIPS and CASH and CASP8AP1 and Casper and CLARP and FLAME and FLAME-1 and FLAME1 and FLIP and I-FLICE and MRIT, caspase 8, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, death effector domain binding, identical protein binding, leucine rich repeat containing receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042110 and T cell activation and biological process this GO :0042113 and B cell activation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045471 and response to ethanol and biological process this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0046677 and response to antibiotic and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051603 and proteolysis involved in cellular protein catabolic process and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0060715 and syncytiotrophoblast cell differentiation involved in labyrinthine layer development and biological process this GO :0070243 and regulation of thymocyte apoptotic process and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071407 and cellular response to organic cyclic compound and biological process this GO :0097110 and scaffold protein binding and molecular function this GO :0097153 and cysteine-type endopeptidase activity involved in apoptotic process and molecular function this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097194 and execution phase of apoptosis and biological process this GO :0097199 and cysteine-type endopeptidase activity involved in apoptotic signaling pathway and molecular function this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :0097342 and ripoptosome and cellular component this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :2001233 and regulation of apoptotic signaling pathway and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, nuclei, this GO :0001525 and angiogenesis and biological process this GO :0001841 and neural tube formation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005815 and microtubule organizing center and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006508 and proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0007507 and heart development and biological process this GO :0008233 and peptidase activity and molecular function this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0009409 and response to cold and biological process this GO :0016032 and viral process and biological process this GO :0030101 and natural killer cell activation and biological process this GO :0030225 and macrophage differentiation and biological process this GO :0030690 and Noc1p-Noc2p complex and cellular component this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032025 and response to cobalt ion and biological process this GO :0032355 and response to estradiol and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002020 and protease binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0002821 and positive regulation of adaptive immune response and biological process this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016032 and viral process and biological process this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0032813 and tumor necrosis factor receptor superfamily binding and molecular function this GO :0033077 and T cell differentiation in thymus and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043029 and T cell homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048535 and lymph node development and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051607 and defense response to virus and biological process this GO :0060340 and positive regulation of type I interferon-mediated signaling pathway and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0070236 and negative regulation of activation-induced cell death of T cells and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0097049 and motor neuron apoptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097342 and ripoptosome and cellular component this GO :0097527 and necroptotic signaling pathway and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000454 and positive regulation of CD8-positive, this GO :0002020 and protease binding and molecular function this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0005123 and death receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006508 and proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007519 and skeletal muscle tissue development and biological process this GO :0008047 and enzyme activator activity and molecular function this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0014732 and skeletal muscle atrophy and biological process this GO :0014842 and regulation of satellite cell proliferation and biological process this GO :0014866 and skeletal myofibril assembly and biological process this GO :0016032 and viral process and biological process this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0035877 and death effector domain binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043403 and skeletal muscle tissue regeneration and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0060544 and regulation of necroptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097342 and ripoptosome and cellular component this GO :1901740 and negative regulation of myoblast fusion and biological process this GO :1902042 and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0002020: protease binding, this GO :0002020: protease binding, this GO :0002020: protease binding and also this GO :0004197: cysteine-type endopeptidase activity and also this GO :0005123: death receptor binding and also this GO :0005515: protein binding and also this GO :0008047: enzyme activator activity and also this GO :0008234: cysteine-type peptidase activity and also this GO :0032403: protein complex binding and also this GO :0035877: death effector domain binding, this GO :0002020: protease binding and also this GO :0005123: death receptor binding and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0032403: protein complex binding and also this GO :0032813: tumor necrosis factor receptor superfamily binding and also this GO :0035877: death effector domain binding and also this GO :0042802: identical protein binding, this GO :0004175: endopeptidase activity, this GO :0004175: endopeptidase activity and also this GO :0004197: cysteine-type endopeptidase activity and also this GO :0005123: death receptor binding and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0008233: peptidase activity and also this GO :0008234: cysteine-type peptidase activity and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0032403: protein complex binding and also this GO :0035877: death effector domain binding and also this GO :0046982: protein heterodimerization activity and also this GO :0097110: scaffold protein binding and also this GO :0097153: cysteine-type endopeptidase activity involved in apoptotic process and also this GO :0097199: cysteine-type endopeptidase activity involved in apoptotic signaling pathway, this GO :0004197: cysteine-type endopeptidase activity, this GO :0004197: cysteine-type endopeptidase activity, this GO :0005123: death receptor binding, this GO :0005123: death receptor binding, this GO :0005123: death receptor binding, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0008047: enzyme activator activity, this GO :0008233: peptidase activity, this GO :0008234: cysteine-type peptidase activity, this GO :0008234: cysteine-type peptidase activity, this GO :0031625: ubiquitin protein ligase binding, this GO :0032403: protein complex binding, this GO :0032403: protein complex binding, this GO :0032403: protein complex binding, this GO :0032813: tumor necrosis factor receptor superfamily binding, this GO :0035877: death effector domain binding, this GO :0035877: death effector domain binding, this GO :0035877: death effector domain binding, this GO :0042802: identical protein binding, this GO :0046982: protein heterodimerization activity, this GO :0097110: scaffold protein binding, this GO :0097153: cysteine-type endopeptidase activity involved in apoptotic process, this GO :0097199: cysteine-type endopeptidase activity involved in apoptotic signaling pathway, Fas (TNFRSF6)-associated via death domain |
| Identity | 1876 |
| Gene | CFLAR |
| Long gene name | CASP8 and FADD like apoptosis regulator |
| Synonyms gene | CASP8AP1 |
| Synonyms gene name | CASP8 and FADD-like apoptosis regulator |
| Synonyms | CASH Casper CLARP FLAME FLIP I-FLICE MRIT c-FLIP |
| Locus | 2q33, 1 |
| Discovery year | 1999-05-07 |
| GenBank acession | AF005774 |
| Entrez gene record | 8837 |
| Pubmed identfication | 9208847 9217161 |
| RefSeq identity | NM_003879 |
| Classification | Endogenous ligands Death effector domain containing Death inducing signaling complex |
| Havana BLAST/BLAT | OTTHUMG00000132819 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue