| Long name | 104, 153) Monoclonal Antibody, FLNA (1273CT424 |
| Also known as | 104, 153) Monoclonal Antibody, FLNA (1273CT424 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | FLNA |
| Specificity | This is a highly specific antibody against FLNA |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 104, 1273CT424, 153 |
| Source | Purified His-tagged FLNA protein was used to produced this monoclonal antibody |
| Gene ID number | 2316 |
| Swiss Prot | P21333 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:1000-4000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins, Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate, Involved in ciliogenesis, Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, Tethers cell surface-localized furin, heart and brain organs, modulates its rate of internalization and directs its intracellular trafficking (By similarity), resulting in by platelet cytoskeleton organization maintainance (By similarity), Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins |
| Purification method | This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ABP-280, ABPX, Actin-binding protein 280, Alpha-filamin, CSBS, CVD1, Endothelial actin-binding protein, FLN-A, FLN1, FLNA, FMD, Filamin-1, Filamin-A, MNS, NHBP, Non-muscle filamin, OPD, OPD1, OPD2, XLVD, XMVD, FLN |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 104, 153) Monoclonal, FLNA (1273CT424 |
| Short name | 104, 153) Monoclonal Antibody, FLNA (1273CT424 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | alpha (1273CT424, 104, 153) monoclonal (Antibody to), filamin A |
| Alternative technique | antibodies |
| Alternative to gene target | ABP-280 and ABPX and CSBS and CVD1 and FLN and FLN-A and FLN1 and FMD and MNS and NHBP and OPD and OPD1 and OPD2 and XLVD and XMVD, FLNA and IDBG-632632 and ENSBTAG00000011190 and 281165, FLNA and IDBG-91003 and ENSG00000196924 and 2316, Flna and IDBG-155134 and ENSMUSG00000031328 and 192176, actin filament binding, alpha, nuclei, this GO :0001837 and epithelial to mesenchymal transition and biological process this GO :0001948 and glycoprotein binding and molecular function this GO :0002576 and platelet degranulation and biological process this GO :0003779 and actin binding and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005802 and trans- this GO lgi network and cellular component this GO :0005829 and cytosol and cellular component this GO :0005884 and actin filament and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007195 and adenylate cyclase-inhibiting dopamine receptor signaling pathway and biological process this GO :0007596 and blood coagulation and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0015629 and actin cytoskeleton and cellular component this GO :0016020 and membrane and cellular component this GO :0017048 and Rho GTPase binding and molecular function this GO :0017160 and Ral GTPase binding and molecular function this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030168 and platelet activation and biological process this GO :0030863 and cortical cytoskeleton and cellular component this GO :0031267 and small GTPase binding and molecular function this GO :0031523 and Myb complex and cellular component this GO :0031532 and actin cytoskeleton reorganization and biological process this GO :0031852 and mu-type opioid receptor binding and molecular function this GO :0034329 and cell junction assembly and biological process this GO :0034394 and protein localization to cell surface and biological process this GO :0034988 and Fc-gamma receptor I complex binding and molecular function this GO :0042177 and negative regulation of protein catabolic process and biological process this GO :0042384 and cilium assembly and biological process this GO :0042789 and mRNA transcription from RNA polymerase II promoter and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042993 and positive regulation of transcription factor import into nucleus and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043113 and receptor clustering and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043198 and dendritic shaft and cellular component this GO :0043234 and protein complex and cellular component this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045022 and early endosome to late endosome transport and biological process this GO :0045184 and establishment of protein localization and biological process this GO :0046332 and SMAD binding and molecular function this GO :0048365 and Rac GTPase binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050821 and protein stabilization and biological process this GO :0051015 and actin filament binding and molecular function this GO :0051220 and cytoplasmic sequestering of protein and biological process this GO :0051764 and actin crosslink formation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0090307 and spindle assembly involved in mitosis and biological process this GO :0097440 and apical dendrite and cellular component, this GO :0001948: glycoprotein binding, this GO :0001948: glycoprotein binding and also this GO :0003779: actin binding and also this GO :0004871: signal transducer activity and also this GO :0005080: protein kinase C binding and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0017048: Rho GTPase binding and also this GO :0017160: Ral GTPase binding and also this GO :0031267: small GTPase binding and also this GO :0031852: mu-type opioid receptor binding and also this GO :0034988: Fc-gamma receptor I complex binding and also this GO :0042803: protein homodimerization activity and also this GO :0044822: poly(A) RNA binding and also this GO :0046332: SMAD binding and also this GO :0048365: Rac GTPase binding and also this GO :0051015: actin filament binding, this GO :0003779: actin binding, this GO :0004871: signal transducer activity, this GO :0005080: protein kinase C binding, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0017048: Rho GTPase binding, this GO :0017160: Ral GTPase binding, this GO :0031267: small GTPase binding, this GO :0031852: mu-type opioid receptor binding, this GO :0034988: Fc-gamma receptor I complex binding, this GO :0042803: protein homodimerization activity, this GO :0044822: poly(A) RNA binding, this GO :0046332: SMAD binding, this GO :0048365: Rac GTPase binding, this GO :0051015: actin filament binding, filamin A |
| Identity | 3754 |
| Gene | FLNA |
| Long gene name | filamin A |
| Synonyms gene | FLN1 FLN OPD2 OPD1 |
| Synonyms gene name | alpha , alpha (actin binding protein 280) filamin A, filamin A |
| Synonyms | ABP-280 |
| Synonyms name | actin binding protein 280 alpha filamin |
| Locus | Xq28 |
| Discovery year | 1993-03-18 |
| GenBank acession | X70082 |
| Pubmed identfication | 8406501 12612583 |
| Havana BLAST/BLAT | OTTHUMG00000022712 |
| Locus Specific Databases | Mental Retardation database |
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