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FLT1 (1453CT519.277.79) Monoclonal Antibody

FLT1 (1453CT519.277.79) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name277, 79) Monoclonal Antibody, FLT1 (1453CT519
Also known as277, 79) Monoclonal Antibody, FLT1 (1453CT519
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFLT1
SpecificityThis is a highly specific antibody against FLT1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1453CT519, 79, 277
SourceThis FLT1 antibody is generated from a mouse immunized with a recombinant protein
Gene ID number2321
Swiss ProtP17948
Tested ApplicationsWB
Recommended dilutionsWB(1:1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Can promote endothelial cell proliferation, Has very high affinity for VEGFA and relatively low protein kinase activity, Isoform 1 phosphorylates PLCG, Its function in promoting cell proliferation seems to be cell-type specific, Ligand binding leads to the activation of several signaling cascades, Likewise, MAPK3/ERK1 and the MAP kinase signaling pathway, May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells, Mediates activation of MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates KDR signaling by forming heterodimers with KDR, Phosphorylates SRC and YES1, Promotes PGF-mediated proliferation of endothelial cells, Promotes phosphorylation of AKT1 at 'Ser-473', VEGFB and PGF, and cancer cell invasion, and may also phosphorylate CBL, and plays an essential role in the development of embryonic vasculature, as well as of the AKT1 signaling pathway, but does not promote proliferation of normal fibroblasts (in vitro), cell migration, cell survival, chemotaxis, isoform 3 and isoform 4, isoforms lacking a transmembrane domain, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway, macrophage function, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR, may function as decoy receptors for VEGFA, proliferation of some types of cancer cells, such as isoform 2, survival and angiogenesis in adulthood, the regulation of angiogenesis, the regulatory subunit of phosphatidylinositol 3-kinase, 4, 5-trisphosphate and the activation of protein kinase C, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA
Purification method This antibody is purified through a protein G column, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FLT-1, FLT1, FRT, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGFR-1, VEGFR1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor, FLT
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target277, 79) Monoclonal, FLT1 (1453CT519
Short name277, 79) Monoclonal Antibody, FLT1 (1453CT519
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name277, 79) monoclonal (Antibody to), FLT1 (1453CT519
Alternative techniqueantibodies
Identity 3763
Gene FLT1
Long gene name fms related tyrosine kinase 1
Synonyms gene FLT
Synonyms gene name fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) fms-related tyrosine kinase 1
Synonyms VEGFR1
Synonyms name vascular endothelial growth factor receptor 1 vascular permeability factor receptor
Locus 13q12, 3
Discovery year 1986-01-01
GenBank acession AF063657
Entrez gene record 2321
Pubmed identfication 2158038
RefSeq identity NM_002019
Classification I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000016648
Locus Specific Databases The Globin Gene Server LRG_425

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