Filters

FMR1 Antibody

FMR1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFMR1 Primary Polyclonal Antibody
Also known asFMR1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFMR1
SpecificityThis is a highly specific antibody against FMR1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FMRP
Gene ID number2332
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing, It contains several features that are characteristics of RNA-binding proteins, Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs, The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene, The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box), which form heterodimers through their N-terminal coiled-coil domains, Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FMR1, FMR1_HUMAN, FMRP, FMRP1, FRAXA, Fragile X mental retardation 1, Fragile X mental retardation 1 protein, POF, POF1, Protein FMR-1, Protein FMR1, FMR 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFMR1
Short nameFMR1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameFMR1 (Antibody to)
Alternative techniqueantibodies
Identity 3775
Gene FMR1
Long gene name fragile X mental retardation 1
Synonyms gene POF1 POF
Synonyms gene name premature ovarian failure 1
Synonyms FMRP FRAXA MGC87458
Locus Xq27, 3
Discovery year 1992-01-17
GenBank acession X69962
Entrez gene record 2332
Pubmed identfication 1572655
RefSeq identity NM_002024
Havana BLAST/BLAT OTTHUMG00000022606
Locus Specific Databases Mental Retardation database LRG_762

Similar products

Subscribe to our Newsletter