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FRAT1 Antibody

FRAT1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFRAT1 Primary Polyclonal Antibody
Also known asFRAT1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFRAT1
SpecificityThis is a highly specific antibody against FRAT1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FRAT1
Gene ID number10023
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway, FRAT2 has been shown to bind xGSK-3, GBP binds to GSK-3 and inhibits this phosphorylation, Like GBP, These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, Wnt signaling is regulated in part by the activity of GSK-3, and they have since been identified as proto-oncogenes involved in tumorigenesis, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development, which phosphorylates and thereby facilitates the degradation of ?catenin, FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FRAT1_HUMAN, Frequently rearranged in advanced T-cell lymphomas, GSK 3 binding protein FRAT1, frequently rearranged in advanced T cell lymphomas, proto oncogene FRAT1, FRAT 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFRAT1
Short nameFRAT1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namefrequently rearranged in advanced T-cellular lymphomas (Antibody to)
Alternative techniqueantibodies
Alternative to gene target Cytoplasm, FRAT1 and IDBG-648818 and ENSBTAG00000007956 and 505664, FRAT1 and IDBG-84511 and ENSG00000165879 and 10023, Peg12 and IDBG-190638 and ENSMUSG00000070526 and 27412, this GO :0005737 and cytoplasm and cellular component this GO :0016055 and Wnt signaling pathway and biological process, frequently rearranged in advanced T-cell lymphomas
Identity 3944
Gene FRAT1
Long gene name FRAT1, WNT signaling pathway regulator
Synonyms gene name frequently rearranged in advanced T-cell lymphomas frequently rearranged in advanced T-cell lymphomas 1
Locus 10q24, 1
Discovery year 2000-04-13
GenBank acession U58975
Entrez gene record 10023
Pubmed identfication 9034327
RefSeq identity NM_005479
Havana BLAST/BLAT OTTHUMG00000018848

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