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FRAT2 Antibody

FRAT2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameFRAT2 Primary Polyclonal Antibody
Also known asFRAT2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenFRAT2
SpecificityThis is a highly specific antibody against FRAT2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FRAT2
Gene ID number23401
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway, FRAT2 has been shown to bind xGSK-3, GBP binds to GSK-3 and inhibits this phosphorylation, Like GBP, These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, Wnt signaling is regulated in part by the activity of GSK-3, and they have since been identified as proto-oncogenes involved in tumorigenesis, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development, which phosphorylates and thereby facilitates the degradation of ?catenin, FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FRAT2_HUMAN, Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetFRAT2
Short nameFRAT2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namefrequently rearranged in advanced T-cellular lymphomas 2 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target FRAT2 and IDBG-648820 and ENSBTAG00000046701 and 539144, FRAT2 and IDBG-84538 and ENSG00000181274 and 23401, Frat2 and IDBG-166307 and ENSMUSG00000047604 and 212398, molecular_function, multiple, this GO :0003674 and molecular function and molecular function this GO :0005575 and cellular component and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0008283 and cell proliferation and biological process this GO :0016055 and Wnt signaling pathway and biological process, this GO :0003674: molecular_function, this GO :0003674: molecular_function, frequently rearranged in advanced T-cell lymphomas 2
Identity 16048
Gene FRAT2
Long gene name FRAT2, WNT signaling pathway regulator
Synonyms gene name frequently rearranged in advanced T-cell lymphomas 2
Synonyms name GSK-3 binding protein FRAT2
Locus 10q24, 1
Discovery year 2001-07-06
GenBank acession AF062739
Entrez gene record 23401
Pubmed identfication 9635432 11237732
RefSeq identity NM_012083
Havana BLAST/BLAT OTTHUMG00000018850

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