Filters

Frizzled 4/CD344 Antibody, Biotin Conjugated

Frizzled 4/CD344 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, Frizzled 4/CD344 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFrizzled 4/CD344
SpecificityThis is a highly specific antibody against Frizzled 4/CD344
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range190-222/537
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human Frizzled 4/CD344
Gene ID number8322
Swiss ProtQ9ULV1
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, In retina, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP), as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but also by a Wnt-independent signaling via binding of norrin (NDP), but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, it can be both activated by Wnt protein-binding, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs, which leads to the activation of disheveled proteins, Receptor for Wnt proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms CD344
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetFrizzled 4/CD344 Conjugated
Short name Conjugated, Frizzled 4/CD344 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, Frizzled 4/CD344 (Antibody to)
Alternative techniqueantibodies
Identity 4042
Gene FZD4
Long gene name frizzled class receptor 4
Synonyms gene EVR1
Synonyms gene name frizzled (Drosophila) homolog 4 exudative vitreoretinopathy 1 frizzled homolog 4 (Drosophila) frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4
Locus 11q14, 2
Discovery year 1998-09-17
GenBank acession AB032417
Entrez gene record 8322
Pubmed identfication 10544037 15024691
RefSeq identity NM_012193
Classification Class F frizzled CD molecules , G protein-coupled receptors
Havana BLAST/BLAT OTTHUMG00000167231

Similar products

Subscribe to our Newsletter