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Frizzled 4/CD344 Antibody, Cy7 Conjugated

Frizzled 4/CD344 Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, Frizzled 4/CD344 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenFrizzled 4/CD344
SpecificityThis is a highly specific antibody against Frizzled 4/CD344
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range190-222/537
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human Frizzled 4/CD344
Gene ID number8322
Swiss ProtQ9ULV1
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, Both pathways seem to involve interactions with G-proteins, In retina, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP), as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, but also by a Wnt-independent signaling via binding of norrin (NDP), but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, inhibition of GSK-3 kinase, it can be both activated by Wnt protein-binding, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes, promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs, which leads to the activation of disheveled proteins, Receptor for Wnt proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms CD344
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetFrizzled 4/CD344 Conjugated
Short name Conjugated, Frizzled 4/CD344 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, Frizzled 4/CD344 (Antibody to)
Alternative techniqueantibodies
Identity 4042
Gene FZD4
Long gene name frizzled class receptor 4
Synonyms gene EVR1
Synonyms gene name frizzled (Drosophila) homolog 4 exudative vitreoretinopathy 1 frizzled homolog 4 (Drosophila) frizzled 4, seven transmembrane spanning receptor frizzled family receptor 4
Locus 11q14, 2
Discovery year 1998-09-17
GenBank acession AB032417
Entrez gene record 8322
Pubmed identfication 10544037 15024691
RefSeq identity NM_012193
Classification Class F frizzled CD molecules , G protein-coupled receptors
Havana BLAST/BLAT OTTHUMG00000167231

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