FRZB Antibody

FRZB Antibody size: 0.1mg 389

Price 389

Size 0.1mg

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Category	Antibody
Concentration	2ml sterile DI water, 5mg/ml if reconstituted with 0
Form	Antigen affinity purified
Conjugation	Unconjugated
Clone	Polyclonal antibody
Recognised antigen	FRZB
Host animal	Rabbit (Oryctolagus cuniculus)
Clonality	Polyclonal (rabbit origin)
Species reactivity	Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications	WB
Recommended dilutions	5-1ug/ml, Western blot: 0
Notes	Titration of the FRZB antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented use	This FRZB antibodyis to be used only for research purposes and not for diagnostics
Gene ID #	2487
Purity	Antigen affinity
Description	Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility, FRZB is a Wnt-binding protein especially important in embryonic development, FRZB is localized in the extracellular plasma membrane, It is a competitor for the cell-surface G-protein receptor Frizzled, It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development, Unlike frizzled, and because of its intracellular C-terminus which is crucial for signaling, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors, FRZB is also known as FRE or OS1
Immunogen	Human partial recombinant protein (AA 176-325) was used as the immunogen for this FRZB antibody
Storage	Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the FRZB antibody can be stored for up to one month at 4oC, After reconstitution
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target	FRZB
Short name	FRZB Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	frizzled-related protein (Antibody to)
Alternative technique	antibodies
Alternative to gene target	Extracellular, FRE and FRITZ and FRP-3 and FRZB-1 and FRZB-PEN and FRZB1 and FZRB and hFIZ and OS1 and SFRP3 and SRFP3, FRZB and IDBG-639871 and ENSBTAG00000010977 and 281170, FRZB and IDBG-76878 and ENSG00000162998 and 2487, Frzb and IDBG-183775 and ENSMUSG00000027004 and 20378, Wnt-activated receptor activity, this GO :0001501 and skeletal system development and biological process this GO :0001944 and vasculature development and biological process this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007420 and brain development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008406 and this GO nad development and biological process this GO :0010721 and negative regulation of cell development and biological process this GO :0014033 and neural crest cell differentiation and biological process this GO :0016020 and membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0030165 and PDZ domain binding and molecular function this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0042472 and inner ear morphogenesis and biological process this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0060029 and convergent extension involved in organogenesis and biological process this GO :0060056 and mammary gland involution and biological process this GO :0060429 and epithelium development and biological process this GO :0061037 and negative regulation of cartilage development and biological process this GO :0061053 and somite development and biological process this GO :0070367 and negative regulation of hepatocyte differentiation and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0090103 and cochlea morphogenesis and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0017147: Wnt-protein binding and also this GO :0030165: PDZ domain binding and also this GO :0042813: Wnt-activated receptor activity, this GO :0017147: Wnt-protein binding, this GO :0030165: PDZ domain binding, this GO :0042813: Wnt-activated receptor activity, frizzled-related protein
Identity	3959
Gene	FRZB
Long gene name	frizzled-related protein
Synonyms	FRZB-PEN FRZB1 SRFP3 FRP-3 SFRP3 FRE FRITZ FRZB-1 FZRB hFIZ
Synonyms name	secreted frizzled-related protein 3
Locus	2q32, 1
Discovery year	1998-07-15
GenBank acession	U24163
Entrez gene record	2487
Pubmed identfication	8824257 9118218
RefSeq identity	NM_001463
Classification	Secreted frizzled-related proteins
Havana BLAST/BLAT	OTTHUMG00000132597

FRZB Antibody

FRZB Antibody size: 0.1mg 389

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