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GAD67 Antibody

GAD67 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameGAD67 Primary Polyclonal Antibody
Also known asGAD67 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenGAD67/GAD1
Specificity Belongs to the group II decarboxylase family, This is a highly specific antibody against GAD67/GAD1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range510-560/594
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GAD67
Gene ID number2571
Swiss ProtQ99259
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen (585 amino acid residues) and is encoded on human chromosome 10, GAD exists as two isoforms, GAD has a restricted tissue distribution, GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, GAD65 and GAD67 (molecular masses of 65 and 67 kD, GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), GAD65 is an ampiphilic, GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2, IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells, Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms, It is also present in other non-neuronal tissues such as testis, It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells, The two isoforms appear to have distinct intraneuronal distribution in the brain, There is 64% amino acid identity between the two isoforms, This suggests that GAD may be an important marker in the early stages of the disease, and a putative paracrine signal molecule in pancreatic islets, membraneanchored protein, oviduct and ovary, respectively) that are encoded by two different genes, suggesting its involvement in development and plasticity, the principal inhibitory neurotransmitter in the brain, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles, with the highest diversity located at the N terminus, Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L glutamate to g-aminobutyric acid (GABA)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 67 kDa glutamic acid decarboxylase, CPSQ1, GAD-67, GAD1, GAD67, Glutamate decarboxylase 1, Glutamate decarboxylase 67 kDa isoform, SCP, GAD
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetGAD67
Short nameGAD67 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGAD67 (Antibody to)
Alternative techniqueantibodies

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