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GFI1B Antibody

GFI1B Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameGFI1B Primary Polyclonal Antibody
Also known asGFI1B PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenGFI1B
SpecificityThis is a highly specific antibody against GFI1B
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GFI1B
Gene ID number8328
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Alters histone methylation by recruiting histone methyltransferase to target genes promoters, Binds to gamma-satellite DNA and to its own promoter, Cooperates with GATA1 to repress target gene transcription, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate, Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells, Plays a role in heterochromatin formation, Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction, Transcriptional repressor or activator depending on both promoter and cell type context, as GATA1 also mediates erythroid GFI1B transcription, auto-repressing its own expression, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells, may regulate cytokine signaling pathways, represses promoter activity of SOCS1 and SOCS3 and thus, such as the apoptosis regulator BCL2L1, Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names GFI 1B, GFI-1B, GFI1B protein, GFI1B_HUMAN, Growth factor independent 1B protein, Growth factor independent protein 1B, Potential regulator of CDKN1A, Translocated in CML, Zinc finger protein Gfi-1b, gfi1b, Potential regulator of CDKN1A translocated in CML
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetGFI1B
Short nameGFI1B Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGFI1B (Antibody to)
Alternative techniqueantibodies
Identity 4238
Gene GFI1B
Long gene name growth factor independent 1B transcriptional repressor
Synonyms gene name growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)
Synonyms ZNF163B
Locus 9q34, 13
Discovery year 1998-09-17
GenBank acession AF081946
Entrez gene record 8328
Pubmed identfication 9878267
RefSeq identity NM_004188
Classification Zinc fingers C2H2-type SNAG transcriptional repressors
Havana BLAST/BLAT OTTHUMG00000020848
Locus Specific Databases LRG_879

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