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GFI1B Antibody, FITC Conjugated

GFI1B Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, GFI1B Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGFI1B
SpecificityThis is a highly specific antibody against GFI1B
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human GFI1B
Gene ID number8328
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Alters histone methylation by recruiting histone methyltransferase to target genes promoters, Binds to gamma-satellite DNA and to its own promoter, Cooperates with GATA1 to repress target gene transcription, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate, Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells, Plays a role in heterochromatin formation, Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction, Transcriptional repressor or activator depending on both promoter and cell type context, as GATA1 also mediates erythroid GFI1B transcription, auto-repressing its own expression, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells, may regulate cytokine signaling pathways, represses promoter activity of SOCS1 and SOCS3 and thus, such as the apoptosis regulator BCL2L1, Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms ZNF163B
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetGFI1B Conjugated
Short name FITC Conjugated, GFI1B Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, GFI1B (Antibody to)
Alternative techniqueantibodies
Identity 4238
Gene GFI1B
Long gene name growth factor independent 1B transcriptional repressor
Synonyms gene name growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)
Locus 9q34, 13
Discovery year 1998-09-17
GenBank acession AF081946
Entrez gene record 8328
Pubmed identfication 9878267
RefSeq identity NM_004188
Classification Zinc fingers C2H2-type SNAG transcriptional repressors
Havana BLAST/BLAT OTTHUMG00000020848
Locus Specific Databases LRG_879

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