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Gigaxonin Antibody, ALEXA FLUOR 488

Gigaxonin Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, Gigaxonin Polyclonal Antibody
Also known asAnti-Gigaxonin PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGigaxonin
SpecificityThis is a highly specific antibody against Gigaxonin
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gigaxonin
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen GAN1, Gigaxonin is a member of the cytoskeletal BTB/kelch repeat family and influences cytoskeletal organization and dynamics, Mutations in the Gigaxonin gene result in human giant axonal neuropathy (GAN), Overexpression of MAP1B may lead to neuronal cell death, The amino terminal BTB domain of gigaxonin binds to the ubiquitin-activating enzyme E1, also refered to as giant axonal neuropathy, an autosomal recessive neurodegenerative disorder characterized by axonal degeneration caused by cytoskeletal abnormalities, and tags it for degredation, controls protein degradation and is essential for neuronal function and survival, including accumulated intermediate filaments, or KLHL16, playing a large role in neurofilament architecture, whereas a reduction of MAP1B significantly improves the survival rate of neurons, while the carboxy-terminal kelch repeat domain interacts directly with the light chain of microtubule-associated protein 1B (MAP1B), Gigaxonin
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms GAN1 KLHL16
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Gigaxonin Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetGigaxonin
Short nameGigaxonin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, Gigaxonin (Antibody to)
Alternative techniqueantibodies
Identity 4137
Gene GAN
Long gene name gigaxonin
Synonyms gene name giant axonal neuropathy (gigaxonin)
Synonyms name kelch-like family member 16
Locus 16q23, 2
Discovery year 1998-09-14
GenBank acession AF291673
Entrez gene record 8139
Pubmed identfication 9450783 11062483
Classification BTB domain containing Kelch like
Havana BLAST/BLAT OTTHUMG00000137627
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LRG_242

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