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Girdin Antibody, ALEXA FLUOR 488

Girdin Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, Girdin Polyclonal Antibody
Also known asAnti-Girdin PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGirdin
SpecificityThis is a highly specific antibody against Girdin
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range1450-1500/1870
Subcellular location Cell membrane, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APE/Girdin
Gene ID Number328
Swiss ProtP27695
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB, Also involved in the DNA cleavage step of class switch recombination (CSR), Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs), May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation, On the other hand, Plays a role in the protection from granzymes-mediated cellular repair leading to cell death, Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks, The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors, and single-stranded RNA molecules, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, single-stranded DNA regions of R-loop structures, such as the FOS/JUN AP-1 complex after exposure to IR, Multifunctional protein that plays a central role in the cellular response to oxidative stress
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms FLJ10392 APE GIV HkRP1 GRDN
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Girdin Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetGirdin
Short nameGirdin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, Girdin (Antibody to)
Alternative techniqueantibodies
Identity 25523
Gene CCDC88A
Long gene name coiled-coil domain containing 88A
Synonyms gene KIAA1212
Synonyms gene name KIAA1212
Synonyms name Galpha-interacting vesicle-associated protein Akt-phosphorylation enhancer girdin girders of actin filaments
Locus 2p16, 1
Discovery year 2004-01-13
GenBank acession AB033038 AF112218
Entrez gene record 55704
Pubmed identfication 15749703 15753085
RefSeq identity NM_017571
Havana BLAST/BLAT OTTHUMG00000151915

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