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Girdin Antibody, Cy5.5 Conjugated

Girdin Antibody, Cy5.5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5, 5 Conjugated, Girdin Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugation Cy5, 5, 5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGirdin
SpecificityThis is a highly specific antibody against Girdin
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range1450-1500/1870
Subcellular location Cell membrane, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human APE/Girdin
Gene ID number328
Swiss ProtP27695
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB, Also involved in the DNA cleavage step of class switch recombination (CSR), Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs), May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation, On the other hand, Plays a role in the protection from granzymes-mediated cellular repair leading to cell death, Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks, The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors, and single-stranded RNA molecules, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, single-stranded DNA regions of R-loop structures, such as the FOS/JUN AP-1 complex after exposure to IR, Multifunctional protein that plays a central role in the cellular response to oxidative stress
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission675nm/694nm
Synonyms AP endonuclease 1, APE-1, APE1, APEN, APEX, APEX nuclease, APEX1, APX, Apurinic-apyrimidinic endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, HAP1, REF-1, REF1, Redox factor-1, APE
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene targetGirdin Conjugated
Short name Conjugated, Girdin Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label5, Cy5
Alternative name cyanine 5, 5 coupled, Girdin (Antibody to)
Alternative techniqueantibodies

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