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GLCNE Antibody, ALEXA FLUOR 555

GLCNE Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, GLCNE Polyclonal Antibody
Also known asAnti-GLCNE PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGLCNE
SpecificityThis is a highly specific antibody against GLCNE
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GLCNE
Gene ID Number10020
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Both IBM2 and NM/DMRV are autosomal recessive neuromuscular disorders characterized by adult onset, Defects in GLCNE are the cause of sialuria, GLCNE is required for normal sialylation in hematopoietic cells, It is also expressed, It is characterized by an accumulation of free sialic acid in the cytoplasm and large quantities of neuraminic acid in the urine, It is upregulated after PKC-dependent phosphorylation and is most abundantly expressed in liver and placenta, Sialuria is an autosomal dominant disorder caused by a lack of feedback inhibition of GLCNE by CMP-NeuAc, Sialylation is implicated in cell adhesion, a precursor of sialic acids, brain, distal and proximal muscle weakness (especially in the legs) and a typical muscle pathology including filamentous inclusions and rimmed vacuoles, in heart, inclusion body myopathy 2 (IBM2) and Nonaka myopathy (NM) or distal myopathy with rimmed vacuoles (DMRV), kidney, lung, or GLCNE, regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), resulting in overproduction of NeuAc, signal transduction, skeletal muscle and pancreas, to a lesser extent, tumorigenicity and metastatic behavior of malignant cells, The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/Mnk)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms Bunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase, DMRV, GLCNE_HUMAN, ManAc kinase, N acylmannosamine kinase, NM, RP23-209M8, UDP GlcNAc 2 epimerase, UDP GlcNAc 2 epimerase/ManAc kinase, Uae1, Uridine diphosphate N acetylglucosamine 2 epimerase, 6, IBM2
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetGLCNE
Short nameGLCNE Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, GLCNE (Antibody to)
Alternative techniqueantibodies

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