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GLCNE Antibody, Cy7 Conjugated

GLCNE Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, GLCNE Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGLCNE
SpecificityThis is a highly specific antibody against GLCNE
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human GLCNE
Gene ID number10020
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Both IBM2 and NM/DMRV are autosomal recessive neuromuscular disorders characterized by adult onset, Defects in GLCNE are the cause of sialuria, GLCNE is required for normal sialylation in hematopoietic cells, It is also expressed, It is characterized by an accumulation of free sialic acid in the cytoplasm and large quantities of neuraminic acid in the urine, It is upregulated after PKC-dependent phosphorylation and is most abundantly expressed in liver and placenta, Sialuria is an autosomal dominant disorder caused by a lack of feedback inhibition of GLCNE by CMP-NeuAc, Sialylation is implicated in cell adhesion, a precursor of sialic acids, brain, distal and proximal muscle weakness (especially in the legs) and a typical muscle pathology including filamentous inclusions and rimmed vacuoles, in heart, inclusion body myopathy 2 (IBM2) and Nonaka myopathy (NM) or distal myopathy with rimmed vacuoles (DMRV), kidney, lung, or GLCNE, regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), resulting in overproduction of NeuAc, signal transduction, skeletal muscle and pancreas, to a lesser extent, tumorigenicity and metastatic behavior of malignant cells, The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/Mnk)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms Bunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase, DMRV, GLCNE_HUMAN, ManAc kinase, N acylmannosamine kinase, NM, RP23-209M8, UDP GlcNAc 2 epimerase, UDP GlcNAc 2 epimerase/ManAc kinase, Uae1, Uridine diphosphate N acetylglucosamine 2 epimerase, 6, IBM2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetGLCNE Conjugated
Short name Conjugated, GLCNE Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, GLCNE (Antibody to)
Alternative techniqueantibodies

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