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GOAT ANTI HUMAN CD274 (C-TERMINAL) Antibody

GOAT ANTI HUMAN CD274 (C-TERMINAL) Antibody size: 100ug 597

Supplier MBS POLYCLONALS 1
Price 597
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-GOAT ANTI HUMAN CD274 (C-TERMINAL)
Alternative name2Caprine ANTI HUMAN CD274 (C-TERMINAL)
Alternative name3Caprinae ANTI Homo sapiens CD274 (C-TERMINAL)
Alternative name4CD274
Alternative name5N/A
Other names B7 homolog 1, B7 homolog 1, CD274 antigen, CD274 molecule, PDCD1 ligand 1, Programmed cell death 1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1, programmed cell death 1 ligand 1 isoform b
Gene nameCD274
Gene name synonimsN/A
Other gene names B7-H, B7-H1, B7H1, B7H1, CD274, PD-L1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1L1, PDCD1LG1, PDCD1LG1, PDL1, PDL1, Programmed death ligand 1, CD274
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismGoat
Species reactivityHuman
Specificity and cross-reactivity B-cells, _x000D__x000D_CD274 acts as both a co-stimulatory and co-inhibitory molecule, _x000D__x000D_Studies have linked the deregulation of CD274 function with many autoimmune diseases and cancers, a cell surface glycoprotein and member of the B7 family of co-stimulatory molecules, and inducible on activated T-cells, and inhibiting T cell proliferation and TCR-mediated activation of IL-2 production, as well as chronic viral and intracellular bacterial infection, co-stimulating early T cell priming, constitutively expressed on macrophages and dendritic cells, differentiation and IL-10 production, endothelial cells and epithelial cells, in response to interferons, otherwise known as PD-L1, through interaction with the receptor CD279/PD-1, CD274 This item specifically recognises an epitope within the C-terminal (CT) region of human CD274
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
ConcentrationIgG concentration 500ug/1000ul
Storage and shipping Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius
Tested for: ELISA (EIA), Western Blot (WB), Immunohistology - Paraffin (IHC)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24°
Gene targetCD274
Short nameGOAT ANTI HUMAN CD274 (C-TERMINAL) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens CD274 molecule (C-TERMINAL) (Antibody to), caprine antibody to H
Alternative techniqueantibodies
Alternative to gene target CD274 and IDBG-47487 and ENSG00000120217 and 29126, Cd274 and IDBG-157249 and ENSMUSG00000016496 and 60533, Cell surfaces, PD-L1 and IDBG-631351 and ENSBTAG00000000095 and 533834, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0012505 and endomembrane system and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0031295 and T cell costimulation and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042130 and negative regulation of T cell proliferation and biological process this GO :0045087 and innate immune response and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :2001181 and positive regulation of interleukin-10 secretion and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, CD274 molecule
Identity 17635
Gene CD274
Long gene name CD274 molecule
Synonyms gene PDCD1LG1
Synonyms gene name programmed cell death 1 ligand 1 CD274 antigen
Synonyms B7-H B7H1 PD-L1 PDL1 B7-H1
Synonyms name B7 homolog 1
Locus 9p24, 1
Discovery year 2003-11-13
GenBank acession AF177937
Entrez gene record 29126
Pubmed identfication 11015443 10581077
RefSeq identity NM_014143
Classification Endogenous ligands C2-set domain containing CD molecules V-set domain containing
Havana BLAST/BLAT OTTHUMG00000019503

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