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GOAT ANTI HUMAN MAML1 (N-TERMINAL) Antibody

GOAT ANTI HUMAN MAML1 (N-TERMINAL) Antibody size: 100ug 597

Supplier MBS POLYCLONALS 1
Price 597
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-GOAT ANTI HUMAN MAML1 (N-TERMINAL)
Alternative name2Caprine ANTI HUMAN MAML1 (N-TERMINAL)
Alternative name3Caprinae ANTI Homo sapiens MAML1 (N-TERMINAL)
Alternative name4MAML1
Alternative name5N/A
Other names Mastermind-like protein 1, N/A, mastermind homolog, mastermind-like 1 (Drosophila), mastermind-like protein 1, mastermind-like protein 1
Gene nameMAML1
Gene name synonimsN/A
Other gene names KIAA0200, MAML1, Mam-1, Mam-1, Mam1, MAML1
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismGoat
Species reactivityHuman
Specificity and cross-reactivity Studies have shown that the NT region of MAML1 interacts with the DNA-binding domain of the tumor suppressor protein p53, _x000D__x000D_MAML1 interacts with the Mediator complex component CDK8 (Cyclin-dependent kinase 8), a widely expressed nuclear protein and member of the mastermind family, and forms a DNA-binding complex with RBPSUH/RBP-J kappa/CBF1, and plays a role in hematopoietic development, and that over-expression of MAML1, by acting as a regulator of Notch-mediated lymphoid cell fate decisions, enhancing the phosphorylation and proteolytic turnover of the Notch intracellular domain (NICD) within the nucleus, greatly increases p53-mediated gene transcription and biological function, playing a vital role in the transcriptional activation of Notch targets, which acts as a crucial coactivator of Notch-mediated transcriptional activation, MAML1 This item specifically recognises an epitope within the N-Terminal (NT) region of human MAML1 (Mastermind-like Protein 1), _x000D_
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
ConcentrationIgG concentration 500ug/1000ul
Storage and shipping Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius
Tested for: ELISA (EIA), Western Blot (WB)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24°
Gene targetMAML1
Short nameGOAT ANTI HUMAN MAML1 (N-TERMINAL) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens MAML1 (N-TERMINAL) (Antibody to), caprine antibody to H
Alternative techniqueantibodies
Identity 13632
Gene MAML1
Long gene name mastermind like transcriptional coactivator 1
Synonyms gene name mastermind (drosophila)-like 1 mastermind-like 1 (Drosophila)
Synonyms KIAA0200 Mam-1
Synonyms name mastermind homolog
Locus 5q35, 3
Discovery year 2001-07-19
GenBank acession D83785
Entrez gene record 9794
Pubmed identfication 11101851 11390662
RefSeq identity NM_014757
Havana BLAST/BLAT OTTHUMG00000163237

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