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GPR30 Antibody

GPR30 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameGPR30 Primary Polyclonal Antibody
Also known asGPR30 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenGPR30
SpecificityThis is a highly specific antibody against GPR30
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range320-360/375
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GPR30
Gene ID number2852
Swiss ProtQ99527
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Associated with EGFR, Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules, Contributes to thymic atrophy by inducing apoptosis, Enhances uterine contractility in response to oxytocin, Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway, Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner, Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons, Inhibits early osteoblast proliferation at growth plate during skeletal development, Inhibits mature adipocyte differentiation and lipid accumulation, Involved in cancer progression regulation, Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells, Mediates pleiotropic functions among others in the cardiovascular, Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death, Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells, Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells, Promotes neuritogenesis in developing hippocampal neurons, Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation, Stimulates cAMP production, Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway, Stimulates uterine epithelial cell proliferation, Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation, activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), cyclin D1), endocrine, immune and central nervous systems, leading to rapid and transient activation of numerous intracellular signaling pathways, may act as a transcription factor activating growth regulatory genes (c-fos, reproductive, G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CEPR, CMKRL2, Chemoattractant receptor-like 2, DRY12, FEG-1, Flow-induced endothelial G-protein coupled receptor 1, G protein-coupled estrogen receptor 1, G-protein coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-Br, GPER, GPER1, GPR30, IL8-related receptor DRY12, LERGU, LERGU2, LyGPR, Lymphocyte-derived G-protein coupled receptor, Membrane estrogen receptor, mER
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetGPR30
Short nameGPR30 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameGPR30 (Antibody to)
Alternative techniqueantibodies
Identity 4485
Gene GPER1
Long gene name G protein-coupled estrogen receptor 1
Synonyms gene CMKRL2 GPR30 GPER
Synonyms gene name G protein-coupled receptor 30
Synonyms FEG-1 GPCR-Br LERGU LERGU2 DRY12 LyGPR CEPR
Locus 7p22, 3
Discovery year 1997-06-12
GenBank acession U63917
Entrez gene record 2852
Pubmed identfication 9479505 17655271
RefSeq identity NM_001039966
Classification G protein-coupled estrogen receptor
Havana BLAST/BLAT OTTHUMG00000023680

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