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GRB10/14 Antibody, Cy5.5 Conjugated

GRB10/14 Antibody, Cy5.5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5, 5 Conjugated, GRB10/14 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugation Cy5, 5, 5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGRB10/14
SpecificityThis is a highly specific antibody against GRB10/14
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range574-594/594
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human GRB10
Gene ID number2887, 2888
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Binds to, Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation, Delays and reduces AKT1 phosphorylation in response to insulin stimulation, GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation, May inhibit NEDD4-mediated degradation of KDR/VEGFR-2, May play a role in mediating insulin-stimulated ubiquitination of INSR, Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6, Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, Positive regulator of the KDR/VEGFR-2 signaling pathway, Recruits NEDD4 to IGF1R, The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation, activated receptors tyrosine kinases, and suppress signals from, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors, increased internalization and degradation by both the proteasomal and lysosomal pathways, leading to IGF1R ubiquitination, leading to proteasomal degradation, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal, Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission675nm/694nm
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene targetGRB10/14 Conjugated
Short name Conjugated, GRB10/14 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label5, Cy5
Alternative name cyanine 5, 5 coupled, GRB10/14 (Antibody to)
Alternative techniqueantibodies
Identity 4564
Gene GRB10
Long gene name growth factor receptor bound protein 10
Synonyms gene name growth factor receptor-bound protein 10
Locus 7p12, 1
Discovery year 1996-05-30
Entrez gene record 2887
RefSeq identity NM_005311
Classification Pleckstrin homology domain containing SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000150622
Locus Specific Databases LRG_1032

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