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GSK-3 Beta Antibody, ALEXA FLUOR 488

GSK-3 Beta Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, GSK-3 Beta Polyclonal Antibody
Also known asAnti-GSK-3 Beta PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismMouse (Mus musculus)
Target AntigenGSK-3 Beta
SpecificityThis is a highly specific antibody against GSK-3 Beta
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range335-380/420
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GSK-3 Beta
Gene ID Number2932
Swiss ProtP49841
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen APC, AXIN1, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes, CTNNB1/beta-catenin, DPYSL2/CRMP2, EIF2B, GSK3B forms a multimeric complex with APC, In Wnt signaling, In skeletal muscle, JUN, MAPT/TAU and MACF1, MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease, May also mediate the development of insulin resistance by regulating activation of transcription factors, NFATC1/NFATC, Phosphorylates JUN at sites proximal to its DNA-binding domain, Phosphorylates MACF1, Phosphorylates MAPT/TAU on 'Thr-548', Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex, Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA), Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase, Requires primed phosphorylation of the majority of its substrates, Wnt signaling and regulation of transcription factors and microtubules, and thereby opposing the action of calcineurin, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair, shutting off NFATC1/NFATC gene regulation, thereby reducing its affinity for DNA, Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms GSK-3 beta, GSK3B, Serine/threonine-protein kinase GSK3B, Glycogen synthase kinase-3 beta
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the GSK-3 Beta Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetGSK-3 Beta
Short nameGSK-3 Beta Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, GSK-3 b (Antibody to)
Alternative techniqueantibodies

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