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GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody, ALEXA FLUOR 488

GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody, ALEXA FLUOR 488 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody
Also known asAnti-GSK3 Alpha/Beta Tyr279+Tyr216 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenGSK3 Alpha/Beta Tyr279+Tyr216
SpecificityThis is a highly specific antibody against GSK3 Alpha/Beta Tyr279+Tyr216
ModificationPhosphorylation
Modification SiteTyr279+Tyr216
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range250-300/483
Subcellular location Cell membrane, Nucleus
SourceKLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha/Beta around the phosphorylation site of Tyr279/Tyr216
Gene ID Number29312932
Swiss ProtP49840
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen APC and AXIN1, CTNNB1/beta-catenin, Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease, In Wnt signaling, Is necessary for the establishment of neuronal polarity and axon outgrowth, May also mediate the development of insulin resistance by regulating activation of transcription factors, May be involved in the regulation of replication in pancreatic beta-cells, Regulates glycogen metabolism in liver, Requires primed phosphorylation of the majority of its substrates, Through phosphorylation of the anti-apoptotic protein MCL1, Wnt signaling and regulation of transcription factors and microtubules, but not in muscle, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), may control cell apoptosis in response to growth factors deprivation, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin, Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms GSK-3 alpha, GSK3A, Serine/threonine-protein kinase GSK3A, Glycogen synthase kinase-3 alpha
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Description is a &alpha, - or alpha protein sometimes glycoprotein present in blood, The GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody
Gene targetGSK3 Alpha/Beta(Tyr279+Tyr216)
Short nameGSK3 Alpha/Beta(Tyr279+Tyr216) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, GSK3 a/b(Tyr279+Tyr216) (Antibody to)
Alternative techniqueantibodies

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